6 ms·

According to this article, it's been (sorta) reproduced once, which is better than most studies. About 40-60% of scientific studies are not reproducible. Given

According to this article, it's been (sorta) reproduced once, which is better than most studies. About 40-60% of scientific studies are not reproducible. Given that, I'd want to see more reproductions. Also, I'm very annoyed by our American culture which tries to fix problems with drugs, rather than preventing them from happening in the first place with good diet, exercise, sleep and stress management.

nemomarx 2y ago
A drug that reduces appetite is kinda tackling good diet, at least.
- cynicalpeace 2y ago
  Keyword is "kinda"
zpeti 2y ago
I agree with your sentiment, but frankly human nature just doesn’t work that way. We don’t have self control. We weren’t evolved for a world of abundance. This is no one’s fault, and it’s everywhere, china is getting fatter than most countries now. Realistically, ozempic is a miracle and it seems to be a solution to numerous issues of our world. It would be nice if it wasn’t so, but apart from the 10% of people who can control themselves (which also causes psychological issues btw), most people just can’t.
- apwell23 2y ago
  It makes your poop sit in your tummy and rot
  - consteval 2y ago
    This isn't true
    - apwell23 2y ago
      which part?
      - consteval 2y ago
        all of it
        apwell23 2y ago
        their own pamphlet is wrong ? "Taking the medication could be linked to ileus, a condition where the intestines temporarily stop functioning. Increase risk of Gastroparesis"
        consteval 2y ago
        That's a side effect, dumbass. Every medicine has side effects. It's not the primary purpose of the drug or even a likely outcome, like you originally implied. Why even bother lying if you don't possess the intelligence to formulate even a shallow deception? You understand that attempting to be deceptive, and then demonstrating you're too stupid for even simple deceptions is worse than if you had just said nothing, right? Some advice: if you have to employ deception to make your argument, your argument is probably shit and probably isn't even worth the sound waves it travels on. So go back to the drawing board and trying coming up with something less fucking stupid.
- cynicalpeace 2y ago
  I reject your assumption that "This is no one’s fault, and it’s everywhere, china is getting fatter than most countries now." It's the food industrial complex's fault, along with many others (politicians, individuals without self control, etc) I lived in rural Colombia for 4 years. People had access to the junk food, but it wasn't consumed very much because the veggies and meat are all produced locally and super tasty and cheap. And the local dishes were extremely meat and veggie based. Oh, and most people know how to cook there. It's not a fact of human nature to be unhealthy. It's a fact of modern culture.
- thefz 2y ago
  Lol, no. There are countries in which obesity is nonexistent.
  - consteval 2y ago
    Typically, because less food is available in day-to-day life. If I sold cigs on every street corner in a "skinny" country like Japan, how confident are you that I wouldn't create a smoking culture? This is not a matter of motivation or discipline. Such thinking is short-sighted.
    - cthalupa 2y ago
      > If I sold cigs on every street corner in a "skinny" country like Japan, how confident are you that I wouldn't create a smoking culture? Considering Japan has long been one of the highest per capita consumers of tobacco, apparently it's quite likely ;)
  - cthalupa 2y ago
    Obesity is on the rise in a huge percentage of developed nations, and not just western ones. Even South Korea has seen a huge spike over the past decade - the amount of obese men /doubled/ between 2009 and 2019. It went up 3x in China between 1993 and 2015, and is on track to be over 20% by the end of the decade. Japan is increasing at a much slower rate, but it's still going up. 25% of people in India are overweight, with that number and morbid obesity numbers also increasing. Basically every country sees obesity rise as the people gain access to the modern diet.
    - thefz 2y ago
      I don't care obesity is rising here and there, the fact that it is culturally induced remains, as it remains that a change lifestyle is the largest defense against obesity. Enjoy the magic pill for the rest of your life.
      - cthalupa 2y ago
        I'm fairly confident in my ability to get back in the same routine I had in my 20s and take myself off of it, but if staying on it is what it takes for me to remain fit and eating well, then sure. I don't mind giving myself an injection twice a week in exchange for good health. If not needing it makes you feel superior, I'm glad you've found a source of self validation.
Tokkemon 2y ago
These aren't preventative drugs, they are to treat people who are already fat.
- cynicalpeace 2y ago
  Where did I say it was a preventative drug?
- baq 2y ago
  Looks like this is not exactly true given they reduce cravings.
Zelphyr 2y ago
I think the food manufacturers are culpable here, and "manufacturer" is really the best word to use. They're more like chemists cobbling together edible compounds than farmers growing things that provide nutrition.
- cynicalpeace 2y ago
  Absolutely. And every time I come on HN to point out processed foods are bad, I always get the feigned confusion "But are cooked carrots a processed food"
consteval 2y ago
> good diet, exercise, sleep and stress management The problem is these are individual solutions. We have a societal-wide problem. These solutions are therefore useless. You can't solve societal problems with individual solutions. For example, I can't say "people shouldn't steal because it's immoral". It's true, and for me or you that might be enough to keep us from stealing. This is an individual solution. The societal solution is how do you demotivate people from stealing? Now we're not talking about morals. We're talking about economics, poverty, crime prevention, the criminal-industrial complex, etc. If you're waiting around for the day that American "culture" magically reverses itself and everyone wants to be healthy by their own accord, it will never come. If you want an example of changing "culture", look at smoking. Hint: it has nothing to do with "being healthier". The changes we made were not about that.
- cynicalpeace 2y ago
  Culture definitely changes, or else there would be no different cultures. I like bottom-up way to approach it, rather than only top-down via policy. Be healthy yourself and hopefully that bleeds out to your family and friends. If enough people do it, you have a different culture. Certainly possible given all the cultures that do prioritize these things.
  - consteval 2y ago
    > If enough people do it, you have a different culture This just straight up does not work. I will be blunt - you are not suggesting a solution, you're suggesting a delusion. This "do nothing and hope it works" approach is not novel. It has been our one singular approach to the obesity epidemic. Has it been working? We have many decades of evidence now. No, it hasn't. I could maybe see your perspective better if what you're suggesting is not already tried and tested. When you do something for decades at a time and the problem doesn't improve, but in fact gets worse, you have to face the reality that what you're doing just doesn't work. > Certainly possible given all the cultures that do prioritize these things They really don't. They just have less access to food. Some, like Japan, get around obesity by instead having some of the highest tobacco use in the world in combination with a stressed-out population. As fun as it sounds to reintroduce smoking culture to offset obesity, I think it might make more sense to give people access to safe drugs that help regulate their propensity for overconsumption.

nemomarx 2y ago

A drug that reduces appetite is kinda tackling good diet, at least.

cynicalpeace 2y ago
Keyword is "kinda"

zpeti 2y ago

I agree with your sentiment, but frankly human nature just doesn’t work that way. We don’t have self control. We weren’t evolved for a world of abundance. This is no one’s fault, and it’s everywhere, china is getting fatter than most countries now. Realistically, ozempic is a miracle and it seems to be a solution to numerous issues of our world. It would be nice if it wasn’t so, but apart from the 10% of people who can control themselves (which also causes psychological issues btw), most people just can’t.

apwell23 2y ago
It makes your poop sit in your tummy and rot
- consteval 2y ago
  This isn't true
  - apwell23 2y ago
    which part?
    - consteval 2y ago
      all of it
      - apwell23 2y ago
        their own pamphlet is wrong ? "Taking the medication could be linked to ileus, a condition where the intestines temporarily stop functioning. Increase risk of Gastroparesis"
        consteval 2y ago
        That's a side effect, dumbass. Every medicine has side effects. It's not the primary purpose of the drug or even a likely outcome, like you originally implied. Why even bother lying if you don't possess the intelligence to formulate even a shallow deception? You understand that attempting to be deceptive, and then demonstrating you're too stupid for even simple deceptions is worse than if you had just said nothing, right? Some advice: if you have to employ deception to make your argument, your argument is probably shit and probably isn't even worth the sound waves it travels on. So go back to the drawing board and trying coming up with something less fucking stupid.
cynicalpeace 2y ago
I reject your assumption that "This is no one’s fault, and it’s everywhere, china is getting fatter than most countries now." It's the food industrial complex's fault, along with many others (politicians, individuals without self control, etc) I lived in rural Colombia for 4 years. People had access to the junk food, but it wasn't consumed very much because the veggies and meat are all produced locally and super tasty and cheap. And the local dishes were extremely meat and veggie based. Oh, and most people know how to cook there. It's not a fact of human nature to be unhealthy. It's a fact of modern culture.
thefz 2y ago
Lol, no. There are countries in which obesity is nonexistent.
- consteval 2y ago
  Typically, because less food is available in day-to-day life. If I sold cigs on every street corner in a "skinny" country like Japan, how confident are you that I wouldn't create a smoking culture? This is not a matter of motivation or discipline. Such thinking is short-sighted.
  - cthalupa 2y ago
    > If I sold cigs on every street corner in a "skinny" country like Japan, how confident are you that I wouldn't create a smoking culture? Considering Japan has long been one of the highest per capita consumers of tobacco, apparently it's quite likely ;)
- cthalupa 2y ago
  Obesity is on the rise in a huge percentage of developed nations, and not just western ones. Even South Korea has seen a huge spike over the past decade - the amount of obese men /doubled/ between 2009 and 2019. It went up 3x in China between 1993 and 2015, and is on track to be over 20% by the end of the decade. Japan is increasing at a much slower rate, but it's still going up. 25% of people in India are overweight, with that number and morbid obesity numbers also increasing. Basically every country sees obesity rise as the people gain access to the modern diet.
  - thefz 2y ago
    I don't care obesity is rising here and there, the fact that it is culturally induced remains, as it remains that a change lifestyle is the largest defense against obesity. Enjoy the magic pill for the rest of your life.
    - cthalupa 2y ago
      I'm fairly confident in my ability to get back in the same routine I had in my 20s and take myself off of it, but if staying on it is what it takes for me to remain fit and eating well, then sure. I don't mind giving myself an injection twice a week in exchange for good health. If not needing it makes you feel superior, I'm glad you've found a source of self validation.

Tokkemon 2y ago

These aren't preventative drugs, they are to treat people who are already fat.

cynicalpeace 2y ago
Where did I say it was a preventative drug?
baq 2y ago
Looks like this is not exactly true given they reduce cravings.

Zelphyr 2y ago

I think the food manufacturers are culpable here, and "manufacturer" is really the best word to use. They're more like chemists cobbling together edible compounds than farmers growing things that provide nutrition.

cynicalpeace 2y ago
Absolutely. And every time I come on HN to point out processed foods are bad, I always get the feigned confusion "But are cooked carrots a processed food"

consteval 2y ago

> good diet, exercise, sleep and stress management The problem is these are individual solutions. We have a societal-wide problem. These solutions are therefore useless. You can't solve societal problems with individual solutions. For example, I can't say "people shouldn't steal because it's immoral". It's true, and for me or you that might be enough to keep us from stealing. This is an individual solution. The societal solution is how do you demotivate people from stealing? Now we're not talking about morals. We're talking about economics, poverty, crime prevention, the criminal-industrial complex, etc. If you're waiting around for the day that American "culture" magically reverses itself and everyone wants to be healthy by their own accord, it will never come. If you want an example of changing "culture", look at smoking. Hint: it has nothing to do with "being healthier". The changes we made were not about that.

cynicalpeace 2y ago
Culture definitely changes, or else there would be no different cultures. I like bottom-up way to approach it, rather than only top-down via policy. Be healthy yourself and hopefully that bleeds out to your family and friends. If enough people do it, you have a different culture. Certainly possible given all the cultures that do prioritize these things.
- consteval 2y ago
  > If enough people do it, you have a different culture This just straight up does not work. I will be blunt - you are not suggesting a solution, you're suggesting a delusion. This "do nothing and hope it works" approach is not novel. It has been our one singular approach to the obesity epidemic. Has it been working? We have many decades of evidence now. No, it hasn't. I could maybe see your perspective better if what you're suggesting is not already tried and tested. When you do something for decades at a time and the problem doesn't improve, but in fact gets worse, you have to face the reality that what you're doing just doesn't work. > Certainly possible given all the cultures that do prioritize these things They really don't. They just have less access to food. Some, like Japan, get around obesity by instead having some of the highest tobacco use in the world in combination with a stressed-out population. As fun as it sounds to reintroduce smoking culture to offset obesity, I think it might make more sense to give people access to safe drugs that help regulate their propensity for overconsumption.