3 ms·

GLP-1 have already been on the mass market longer than Fen-Phen (7-years for Fen-Phen Vs. 15+ years, even just Semaglutide has been available longer than Fen-Ph

GLP-1 have already been on the mass market longer than Fen-Phen (7-years for Fen-Phen Vs. 15+ years, even just Semaglutide has been available longer than Fen-Phen now, and Semaglutide is a third-gen GLP-1). Honestly, this retort can be made about any/all new drugs entering the market. If you had a legitimate retort/critique I'm sure you would have presented it, but this is all we get. This is what happens when you start out with "[thing] is bad" then work backwards to figure out a reason.

ikanreed 2y ago
Ultimately the main reason it's bad right now is it's expensive. Far beyond the amount needed to recoup research investment and far far far far far far far far far beyond what it takes to synthesize. Low-end cost of $1000 a month is a lot. That's an expensive car lease, or half a cheap mortgage.
- Someone1234 2y ago
  I fully agree. Least of all because it is sold at between $60-200 abroad full-priced. Those countries just have price controls; the pharmacies are still making 80%+ profit margins in those places. Ultimately, a lot of people will literally die because of this greed. That isn't hyperbole.
- tptacek 2y ago
  These things are priced against their alternatives, and so are almost definitionally less expensive than the status quo ante.
- rustcleaner 2y ago
  Suddenly it's a national security issue. Suddenly USGov issues emergency production licenses and orders domestically to drop that down to effectively $0.10/kilodose on the market. Suddenly when Denmark (or whoever) whines, USGov sends a cumulative NATO military defense bill, tells them they are the reserve currency, they have bigger nukes, and tough shit next time don't pork barrel the American people. Lots of options for Americans; question is, can we be unprincipled enough to take the steps neccessary? :^)
AStonesThrow 2y ago
I mean it's literally as if people don't understand how drugs work, or what drugs actually do to human bodies. It is as if those who do not remember the past are repeating it, already. So many shills are singing the praises of this wonder drug. In India we're all the rave Discovered that it's great as aftershave, oh-ho Dropped in the sea just off Japan Swapped twenty bottles for an aqua-walkman, oh Immunity from ridicule Improves your brains if you're a fool, oh-ho And I read in the Middle East Traded some for a hostage release Now if you're bald it'll give you hair If you've got straight trousers it'll give you flares Feeling up you'll get depressed Out of style here's a brand new dress, oh It was really vile weather When we got tarred and feathered You could hear the six-guns sound As they chased us out of town

ikanreed 2y ago

Ultimately the main reason it's bad right now is it's expensive. Far beyond the amount needed to recoup research investment and far far far far far far far far far beyond what it takes to synthesize. Low-end cost of $1000 a month is a lot. That's an expensive car lease, or half a cheap mortgage.

Someone1234 2y ago
I fully agree. Least of all because it is sold at between $60-200 abroad full-priced. Those countries just have price controls; the pharmacies are still making 80%+ profit margins in those places. Ultimately, a lot of people will literally die because of this greed. That isn't hyperbole.
tptacek 2y ago
These things are priced against their alternatives, and so are almost definitionally less expensive than the status quo ante.
rustcleaner 2y ago
Suddenly it's a national security issue. Suddenly USGov issues emergency production licenses and orders domestically to drop that down to effectively $0.10/kilodose on the market. Suddenly when Denmark (or whoever) whines, USGov sends a cumulative NATO military defense bill, tells them they are the reserve currency, they have bigger nukes, and tough shit next time don't pork barrel the American people. Lots of options for Americans; question is, can we be unprincipled enough to take the steps neccessary? :^)

AStonesThrow 2y ago

I mean it's literally as if people don't understand how drugs work, or what drugs actually do to human bodies. It is as if those who do not remember the past are repeating it, already. So many shills are singing the praises of this wonder drug. In India we're all the rave Discovered that it's great as aftershave, oh-ho Dropped in the sea just off Japan Swapped twenty bottles for an aqua-walkman, oh Immunity from ridicule Improves your brains if you're a fool, oh-ho And I read in the Middle East Traded some for a hostage release Now if you're bald it'll give you hair If you've got straight trousers it'll give you flares Feeling up you'll get depressed Out of style here's a brand new dress, oh It was really vile weather When we got tarred and feathered You could hear the six-guns sound As they chased us out of town