For extremely simple scripts maybe. I get around 70 ms difference in startup time. $ time python3 -c "print('Hello world')" Hello world real 0m0.017s

For extremely simple scripts maybe. I get around 70 ms difference in startup time. $ time python3 -c "print('Hello world')" Hello world real 0m0.017s $ time node -e "console.log('Hello world')" Hello world real 0m0.084s