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You shouldn't compare mega doses for shrooms vs acid, they both hit very differently shrooms feel kind of weak until you get to mega dose territory I wouldn't

You shouldn't compare mega doses for shrooms vs acid, they both hit very differently shrooms feel kind of weak until you get to mega dose territory I wouldn't recommend a shroom mega dose either, it feels too chaotic to take anything away from

seec 2y ago
I very much disagree, the effects are extremely similar, to the point where if one could match the active substance dosage as well as absorption rate, you would be very hard pressed to tell the difference. The relative difference is because people generally don't process their shrooms very well and they take much longer to digest (slower release over time) and also its very impossible to judge the potency of the shrooms beforehand (so most go on the safe side dosage); as a starter shrooms are more unpredictable than truffles. I had the same argument with a friend who gave me a bit of LSD (total dosage unknown, it was edible) and I tried a few days ago, it was basically the same as good shrooms. In fact, I believe the dose was on the low side, it was faster to take action but the "core" experience was shorter and "lower" than just 15 grams of good truffles. The only thing with LSD is that it takes longer to completely clear out of your system (because it is already extracted in pure form, while shrooms have to be digested/processed by your system in a less efficient/effective way) but I don't like that very much because you end up in this in-between state where you are clearly not high anymore but also restless with secondary effects that are not really cool/interesting. In any case it would be rather surprising if it was different, because molecularly they are extremely close.
- jrflowers 2y ago
  None of this is true, for various reasons. Psilocybin and LSD are qualitatively different above very low doses. They have a lot in common, but only a person that is basically unfamiliar with one or both would call them identical. The experiences become more distinct the higher the dose. Psilocybin/psilocin has different binding affinities than LSD, is metabolized differently etc. They are, quite simply, different drugs. >The only thing with LSD is that it takes longer to completely clear out of your system (because it is already extracted in pure form, while shrooms have to be digested/processed by your system in a less efficient/effective way This is borderline gibberish. The “purity” of the “extraction” (???) has nothing to do with metabolism, protein binding or excretion. The LSD expense typically lasts longer because… it is a different drug. Your body treats it differently than psilocybin because it is different from psilocybin. And the molecules do not look that much alike, unless you think that all indoles look alike. Even if they did, molecules that look alike do not necessarily act alike (eg H2O and H2O2) Psilocybin: https://en.m.wikipedia.org/wiki/Psilocybin#/media/File%253APsilocybin%252C_Kekul%C3%A9%252C_skeletal_formula_of_canonical_psilocybin.svg https://en.m.wikipedia.org/wiki/Psilocybin#/media/File%253AP... LSD: https://en.m.wikipedia.org/wiki/LSD#/media/File%3ALSD_Structure_V2.svg https://en.m.wikipedia.org/wiki/LSD#/media/File%3ALSD_Struct...

seec 2y ago

I very much disagree, the effects are extremely similar, to the point where if one could match the active substance dosage as well as absorption rate, you would be very hard pressed to tell the difference. The relative difference is because people generally don't process their shrooms very well and they take much longer to digest (slower release over time) and also its very impossible to judge the potency of the shrooms beforehand (so most go on the safe side dosage); as a starter shrooms are more unpredictable than truffles. I had the same argument with a friend who gave me a bit of LSD (total dosage unknown, it was edible) and I tried a few days ago, it was basically the same as good shrooms. In fact, I believe the dose was on the low side, it was faster to take action but the "core" experience was shorter and "lower" than just 15 grams of good truffles. The only thing with LSD is that it takes longer to completely clear out of your system (because it is already extracted in pure form, while shrooms have to be digested/processed by your system in a less efficient/effective way) but I don't like that very much because you end up in this in-between state where you are clearly not high anymore but also restless with secondary effects that are not really cool/interesting. In any case it would be rather surprising if it was different, because molecularly they are extremely close.

jrflowers 2y ago
None of this is true, for various reasons. Psilocybin and LSD are qualitatively different above very low doses. They have a lot in common, but only a person that is basically unfamiliar with one or both would call them identical. The experiences become more distinct the higher the dose. Psilocybin/psilocin has different binding affinities than LSD, is metabolized differently etc. They are, quite simply, different drugs. >The only thing with LSD is that it takes longer to completely clear out of your system (because it is already extracted in pure form, while shrooms have to be digested/processed by your system in a less efficient/effective way This is borderline gibberish. The “purity” of the “extraction” (???) has nothing to do with metabolism, protein binding or excretion. The LSD expense typically lasts longer because… it is a different drug. Your body treats it differently than psilocybin because it is different from psilocybin. And the molecules do not look that much alike, unless you think that all indoles look alike. Even if they did, molecules that look alike do not necessarily act alike (eg H2O and H2O2) Psilocybin: https://en.m.wikipedia.org/wiki/Psilocybin#/media/File%253APsilocybin%252C_Kekul%C3%A9%252C_skeletal_formula_of_canonical_psilocybin.svg https://en.m.wikipedia.org/wiki/Psilocybin#/media/File%253AP... LSD: https://en.m.wikipedia.org/wiki/LSD#/media/File%3ALSD_Structure_V2.svg https://en.m.wikipedia.org/wiki/LSD#/media/File%3ALSD_Struct...