> Also, what's up with drug studies always having such a low sample size? Is it really that hard to find people who'd volunteer to get free drugs? They try to

> Also, what's up with drug studies always having such a low sample size? Is it really that hard to find people who'd volunteer to get free drugs? They try to make for no comorbidities and and for MDD that is pretty rare. It also means that we’re often studying rare configurations compared to those commonly seen in actual practice. Statistics doesn’t like confounding elements and humans are very confounding. So either you get “bad” statistics, or you get “bad” data. And why you have front line drugs that only have a helpful effect for 33% of people.