According to cursory search: TL,DR: They've confirmed the discovery of his remains, based on DNA. "DNA evidence has confirmed that the remains buried in Sevil

According to cursory search: TL,DR: They've confirmed the discovery of his remains, based on DNA. "DNA evidence has confirmed that the remains buried in Seville's Cathedral of Saint Mary of the See really are Christopher Columbus" https://www.bbc.com/news/articles/c2ek271jxpvo https://www.bbc.com/news/articles/c2ek271jxpvo