From what I recall, SSRIs only show an effect greater than placebo in major depression, and that effect goes away if the placebo is active (i.e. the placebo mak

From what I recall, SSRIs only show an effect greater than placebo in major depression, and that effect goes away if the placebo is active (i.e. the placebo makes you a little sick, so you can "feel it working.") Great idea to compare a new trendy treatment with promise of potential financial windfalls to another treatment that barely works. If you kept feeding them cocaine under medical supervision, they'd probably report feeling slightly better, too. They're recreational drugs. People take them because they feel good. The most common symptom of depression is to take refuge in drug consumption.