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I've never found it compelling that blinding isn't possible for drug-naive patients. There are other drugs that could induce a "trip" and an unfamiliar individu
by dontwearitout 2y ago
I've never found it compelling that blinding isn't possible for drug-naive patients. There are other drugs that could induce a "trip" and an unfamiliar individual could mistake for a minor psychedelic experience.
- idunnoman1222 2y agoReally? name one.
- dontwearitout 2y agoDissociatives would work, like dextromethorphan or ketamine. Psychedelics are a subset of hallucinogens.
- idunnoman1222 2y agoketamine is great for depression
- GuB-42 2y agoWhen you don't know what a psychedelic experience is, any mind altering substance could do. For someone who never got drunk, it could even include alcohol. It is very hard to describe in words what a psychedelic experience is, so without a reference point, it is hard to tell if what you experienced is one or not.
- idunnoman1222 2y agoIs alcohol the best you could do? I have a feeling that alcohol can definitely help with depression Probably one of the oldest drugs used in that regard of course there aren’t actually that many drugs.. you clearly couldn’t give another tryptamine they are kindof all the same. I guess you could give a phenethylamine but obviously those are probably good at treating depression too so your studies gone to shit I suppose you could give a deliriant but that just sounds mean.
- franga2000 2y agoOk but now you're not comparing drug vs no drug but drug vs other drug. Yes it can be blind, but it's a cometely different study now
- GuB-42 2y agoSuggestion alone can make you feel high. I remember someone telling me that he got high just by touching sweaty people in a music festival where most people were high, clearly, that's placebo. And that guy was far from drug-naive. And they sometimes give active substances to the control arm to have an effect. I remember in a covid vaccine trial, they gave the meningitis vaccine to the control group to mimic the side effects of the covid vaccine they tried. Here, they actually gave a microdose of psilocybin (1mg) to the SSRI arm. I don't know why, but maybe it was enough for them to feel something without having the full effect.