4 ms·
> we do not know, really, what goes on in there when you take a drug like Psilocybin FYI, same goes for SSRIs. The scientific consensus is that the serotonin d
by dimal 2y ago
> we do not know, really, what goes on in there when you take a drug like Psilocybin
FYI, same goes for SSRIs. The scientific consensus is that the serotonin deficiency theory of depression was wrong. When SSRIs actually work, we still don’t know why.
I’ve had bad trips, too. Very bad, but I still think that psilocybin (in a controlled, supportive setting) is a better bet. My bad trips were all due to being in bad settings and being completely unprepared for what could go wrong. I was young and dumb and just fucking around. But tripping in positive supportive settings was incredibly helpful. And if we do find a way to do this right, then people don’t have to take drugs for the rest of their lives. Psychiatric drugs are generally lifelong sentences, and negative side effects tend to compound over time, which often leads to polypharmacy, and more side effects.
- DiscourseFan 2y agoI agree. But I don’t think psychedelics are the end all be all, that’s all
- Levitating 2y agoSSRIs barely work. For mild to moderate depression a placebo works similarly or better. Only for severe cases of depression are SSRIs found to be helpful because they surpress all emotion.
- grandpoobah 2y agoWorked great for me. Placebo might have worked too, but doctors don't prescribe those!
- drakonka 2y agoMaybe the effect is different when prescribed for something other than depression, but I did not find my SSRI to suppress my emotions. It simply helps me curb rumination and negative thought spirals. Helps to feel "lighter" and simultaneously more grounded. If anything, that allows me to feel _more_ positive emotion rather than suppressing it.
- hn_version_0023 2y agoCool, glad you had a positive experience. My experience was the opposite: emotionally numb to the point where awfully bad things happened in my presence and I barely shrugged. Being unable to feel joy or pain, being unable to cry when a loved on passed on; these were the hallmarks of my time on SSRIs. Never again will I subject myself to these drugs. It took me twice as long to get off them as I was on them. Two years of prescribed meds, 4 years to get off them. Six years of my life spent as a literal zombie person. We don’t know why they work or don’t. Our experiences are just anecdata.
- worik 2y ago> Our experiences are just anecdata. Just? Anecdotes matter
- dymax78 2y ago~50% response rate for people with major depressive disorder isn't "barely working" -- for millions of people, SSRIs significantly improve their quality of life. Unfortunately, there is no "one size fits all" solution and often those of us with MDD have to try different medications, in conjunction with a (good) therapist before we find what works best. Personally, I've run the gamut on SSRIs and they never suppressed all emotion.
- wetpaws 2y ago[dead]
- zdragnar 2y agoThis is blatantly false. I've been on a few. Some didn't help, some made me worse. The one I'm on now is extremely helpful, and saved me. None of them had any suppressant effects on my emotions at all.
- Levitating 2y agoI was specifically thinking of this paper: https://journals.plos.org/plosmedicine/article?id=10.1371/journal.pmed.0050045 https://journals.plos.org/plosmedicine/article?id=10.1371/jo... As well as the experience of many people close to me that used SSRIs.