Anecdotal case study involving a community of about a hundred enthusiasts: many in this community held the opinion you do, which is that something about the mus

Anecdotal case study involving a community of about a hundred enthusiasts: many in this community held the opinion you do, which is that something about the mushrooms themselves is unique to the psilocin experience (psilocybin is not always present, and in any case, metabolizes to psilocin). Then 4-actyl DMT, sometimes call psilacetin, became broadly available. This is a synthetic pro-drug for psilocin, just as psilocybin is a naturally-occurring pro-drug for psilocin. After that, the opinion that the mushroom per se had anything to do with the experience became very rare. It turns out that psilocin is meaningfully different from, in particular, LSD, 2C-B, and MD(M)A. There's definitely something special about it. But that something is also present when it comes in vitro, not just in vivo.