4 ms·

I wonder how much of an uphill battle it will be to get psilocybin approved for therapeutic use compared to synthetic psilocybin analogues that are being triale

I wonder how much of an uphill battle it will be to get psilocybin approved for therapeutic use compared to synthetic psilocybin analogues that are being trialed right now. Psilocybin can't be patented and it's already scheduled as a narcotic everywhere.

tootie 2y ago
I'm taking a prescription med that is basically a schedule 1 drug that's been very slightly modified and declared schedule 3 and prescribed through a tightly controlled program. I'm even taking a generic version.
- deleted 2y ago
  [deleted]
- mtlmtlmtlmtl 2y ago
  Purely out of curiosity, which drug is this, if you don't mind me asking?
  - tootie 2y ago
    Sodium oxybate. Active ingredient is GHB. I was stunned to find out this was a therapeutic but apparently it was developed for potential therapies and was only coincidentally discovered to be intoxicating. I used to suffer debilitating cataplexy and sodium oxybate has nearly wiped it out.
    - mtlmtlmtlmtl 2y ago
      Right, GHB is an interesting one. It's always fascinated me how most recreational drugs are a wonderdrug for at least one medical condition. There are a couple of exceptions of course. Like synthetic cannabinoids. But even ethanol can be used as an antidote for methanol poisoning. For me it's amphetamine. I have severe dehabilitating ADHD-C and lisdexamphetamine has completely changed my life.
pier25 2y ago
It's already being used in therapy. Oregon is giving licenses. https://www.oregon.gov/oha/ph/preventionwellness/pages/psilocybin-license-facilitator.aspx https://www.oregon.gov/oha/ph/preventionwellness/pages/psilo...
- Der_Einzige 2y ago
  In Oregon enforcement of what passes for our drug laws here is so lax (cops quiet quit long before covid) that it's de-facto legalized. I've literally walked down Portland and had random homeless people unprompted yell out "Want to buy some shrooms?" There have been unlicensed openly practicing shrooms businesses which survived far longer than one would expect for such a "regulated" industry.
Muromec 2y ago
I doubt about everywhere, as shrooms are sold in shop around here.
- chiefalchemist 2y ago
  Where is here?
  - foolfoolz 2y ago
    california has mushroom stores
  - Muromec 2y ago
    Clearly not North America
- dymk 2y ago
  In the US, those aren’t from mushrooms that contain psilocybin or related neurotransmitter analogs
  - snozolli 2y ago
    It definitely happens: https://www.seattletimes.com/business/oregon-store-allegedly-selling-psychedelic-mushrooms-raided/ https://www.seattletimes.com/business/oregon-store-allegedly... https://www.sfgate.com/cannabis/article/sf-magic-mushroom-churches-government-response-18279694.php https://www.sfgate.com/cannabis/article/sf-magic-mushroom-ch...
cpucycling7 2y ago
Geneva is home to the only Swiss hospital offering psychedelic-assisted therapy. [0] Also, Peter Gasser, a Swiss therapist acquainted with LSD during the 1988-1993 window, was granted approval to carry out the first controlled study of LSD-assisted psychotherapy in more than 40 years. [1] [0] https://www.swissinfo.ch/eng/science/can-psychedelics-therapy-go-mainstream/81974796 https://www.swissinfo.ch/eng/science/can-psychedelics-therap... [1] https://theswisstimes.ch/lsd-and-magic-mushrooms-how-switzerland-became-the-breeding-ground-for-psychedelics/ https://theswisstimes.ch/lsd-and-magic-mushrooms-how-switzer...
Jerrrrrrry 2y ago
The 2018 Hemp Farm bill gave the balls back to the citizens that the 2013 Analag act neutered. Seeing mushroom extracts with all the alkaloids included besides psilocybin at gas stations may be a temporary point of stability until I can go to the "21+" store in 2030 to get my preferred arylcyclohexylamine and phenylethylamine variant.
- dymk 2y ago
  From what I understand, those “magic mushroom” edibles sold in head shops and gas stations are amanita muscaria derived, which is a completely different psychoactive substance with different alkaloids. Toxic to the liver too, in ways that a cubensis is not.
  - tastyfreeze 2y ago
    Northern shamans drank reindeer urine after the animals had eaten amanita muscaria. Passing through the animals reduced the toxic component but left enough alkaloid to trip balls. Maybe the gas station edibles have removed the toxin.
    - roywiggins 2y ago
      signs point to no: https://www.cbsnews.com/news/magic-mushrooms-found-in-recalled-diamond-shruumz-poison-control-confirms/ https://www.cbsnews.com/news/magic-mushrooms-found-in-recall...
    - dymk 2y ago
      Personally, I trust gas station drugs as much as I trust their tuna sandwiches
  - Jerrrrrrry 2y ago
    I was aware but I should know to put disclaimers in drug posts on HN at this point, as others may not be; thank you. That being said, it did have an uncomfortable but brief 'burning/cleansing' feeling reminiscent of Lyseragmides that that most tryptamines / 4-aco-DMT / penis envy / cubensis / 5-MEO-[xxx] did not, and more visual distortions with notably less headfuckery / low body load. I recommend a single try; the tolerance seemed to eliminate effects nearly immediately.

tootie 2y ago

I'm taking a prescription med that is basically a schedule 1 drug that's been very slightly modified and declared schedule 3 and prescribed through a tightly controlled program. I'm even taking a generic version.

deleted 2y ago
[deleted]
mtlmtlmtlmtl 2y ago
Purely out of curiosity, which drug is this, if you don't mind me asking?
- tootie 2y ago
  Sodium oxybate. Active ingredient is GHB. I was stunned to find out this was a therapeutic but apparently it was developed for potential therapies and was only coincidentally discovered to be intoxicating. I used to suffer debilitating cataplexy and sodium oxybate has nearly wiped it out.
  - mtlmtlmtlmtl 2y ago
    Right, GHB is an interesting one. It's always fascinated me how most recreational drugs are a wonderdrug for at least one medical condition. There are a couple of exceptions of course. Like synthetic cannabinoids. But even ethanol can be used as an antidote for methanol poisoning. For me it's amphetamine. I have severe dehabilitating ADHD-C and lisdexamphetamine has completely changed my life.

pier25 2y ago

It's already being used in therapy. Oregon is giving licenses. https://www.oregon.gov/oha/ph/preventionwellness/pages/psilocybin-license-facilitator.aspx https://www.oregon.gov/oha/ph/preventionwellness/pages/psilo...

Der_Einzige 2y ago
In Oregon enforcement of what passes for our drug laws here is so lax (cops quiet quit long before covid) that it's de-facto legalized. I've literally walked down Portland and had random homeless people unprompted yell out "Want to buy some shrooms?" There have been unlicensed openly practicing shrooms businesses which survived far longer than one would expect for such a "regulated" industry.

Muromec 2y ago

I doubt about everywhere, as shrooms are sold in shop around here.

chiefalchemist 2y ago
Where is here?
- foolfoolz 2y ago
  california has mushroom stores
- Muromec 2y ago
  Clearly not North America
dymk 2y ago
In the US, those aren’t from mushrooms that contain psilocybin or related neurotransmitter analogs
- snozolli 2y ago
  It definitely happens: https://www.seattletimes.com/business/oregon-store-allegedly-selling-psychedelic-mushrooms-raided/ https://www.seattletimes.com/business/oregon-store-allegedly... https://www.sfgate.com/cannabis/article/sf-magic-mushroom-churches-government-response-18279694.php https://www.sfgate.com/cannabis/article/sf-magic-mushroom-ch...

cpucycling7 2y ago

Geneva is home to the only Swiss hospital offering psychedelic-assisted therapy. [0] Also, Peter Gasser, a Swiss therapist acquainted with LSD during the 1988-1993 window, was granted approval to carry out the first controlled study of LSD-assisted psychotherapy in more than 40 years. [1] [0] https://www.swissinfo.ch/eng/science/can-psychedelics-therapy-go-mainstream/81974796 https://www.swissinfo.ch/eng/science/can-psychedelics-therap... [1] https://theswisstimes.ch/lsd-and-magic-mushrooms-how-switzerland-became-the-breeding-ground-for-psychedelics/ https://theswisstimes.ch/lsd-and-magic-mushrooms-how-switzer...

Jerrrrrrry 2y ago

The 2018 Hemp Farm bill gave the balls back to the citizens that the 2013 Analag act neutered. Seeing mushroom extracts with all the alkaloids included besides psilocybin at gas stations may be a temporary point of stability until I can go to the "21+" store in 2030 to get my preferred arylcyclohexylamine and phenylethylamine variant.

dymk 2y ago
From what I understand, those “magic mushroom” edibles sold in head shops and gas stations are amanita muscaria derived, which is a completely different psychoactive substance with different alkaloids. Toxic to the liver too, in ways that a cubensis is not.
- tastyfreeze 2y ago
  Northern shamans drank reindeer urine after the animals had eaten amanita muscaria. Passing through the animals reduced the toxic component but left enough alkaloid to trip balls. Maybe the gas station edibles have removed the toxin.
  - roywiggins 2y ago
    signs point to no: https://www.cbsnews.com/news/magic-mushrooms-found-in-recalled-diamond-shruumz-poison-control-confirms/ https://www.cbsnews.com/news/magic-mushrooms-found-in-recall...
  - dymk 2y ago
    Personally, I trust gas station drugs as much as I trust their tuna sandwiches
- Jerrrrrrry 2y ago
  I was aware but I should know to put disclaimers in drug posts on HN at this point, as others may not be; thank you. That being said, it did have an uncomfortable but brief 'burning/cleansing' feeling reminiscent of Lyseragmides that that most tryptamines / 4-aco-DMT / penis envy / cubensis / 5-MEO-[xxx] did not, and more visual distortions with notably less headfuckery / low body load. I recommend a single try; the tolerance seemed to eliminate effects nearly immediately.