5 ms·

The research says you gain the weight back: "For the two in every five patients who discontinue the treatments within a year, according to a 2024 JAMA study, t

The research says you gain the weight back: "For the two in every five patients who discontinue the treatments within a year, according to a 2024 JAMA study, this means that they are likely to rebound to their original weight with less muscle and a higher body fat percentage." The other issue is the muscle loss on being on these drugs as "Clinical data shows that 25 per cent of weight loss from Eli Lilly’s shot resulted from a reduction in lean body mass, including muscle, while 40 per cent of Novo Nordisk’s jab was due to a drop in lean body mass." Via https://www.ft.com/content/094cbf1f-c5a8-4bb3-a43c-988bd8e2dea9 https://www.ft.com/content/094cbf1f-c5a8-4bb3-a43c-988bd8e2d...

JamesBarney 2y ago
Sorry I meant with continued use of the treatment you don't regain the weight. I agree if you stop taking the medication your weight will rebound.
- Alupis 2y ago
  Right, so we doom some portion of the population to forever take a pill from big pharma? How is that acceptable with anyone? The goal should be to use Ozempic until you are in a better place to manage things yourself. The goal should not be to get people hooked on Ozempic for their entire lives. Perhaps Ozempic prescriptions should come with prescribed exercise with check-in and monitoring, or something.
  - rootusrootus 2y ago
    > doom some portion of the population to forever take a pill from big pharma That is temporary. The effects are real. The fact that you don't think big pharma should profit handsomely for making it happen is not the only alternative. Before too long semaglutide, as one example, will be out of patent and available as a generic. It won't cost a thousand bucks a month to big pharma, it'll be practically free. Cheap enough that most insurance plans will likely subsidize it all the way to zero out-of-pocket cost just because the ROI is so good.
  - fragmede 2y ago
    How my decisions will affect some company's bottom line is way behind "will this help me live a better, longer life" in my list of priorities, but I'm already on other medications that are generic for the rest of my life for other genetic defects I've been blessed with, though I'm not on Ozempic.
  - JamesBarney 2y ago
    > Right, so we doom some portion of the population to forever take a pill from big pharma? How is that acceptable with anyone This is literally how almost all medicine works that treats a chronic condition. > Perhaps Ozempic prescriptions should come with prescribed exercise with check-in and monitoring, or something. Why?
    - formerly_proven 2y ago
      [flagged]
      - tomrod 2y ago
        We don't get pissed that elephants don't climb trees. What value is it to characterize people's obesity entirely as slovenness and gluttony? While there are certainly some slobs and glutton, dismissive judgmentality of everyone doesn't make sense. For this reason, I believe your comment is lacking in empathy for people who may struggle differently than you, yet struggle all the same.
      - JamesBarney 2y ago
        Sure of the almost 8 billion people in the world there are plenty who have successfully lost and kept off weight. But if you want to see if there is a reproduceable lifestyle intervention that treats obesity successfully in the long term you can look here. After a few hours of searching you will probably find the same thing I and almost all obesity researchers have concluded. There isn't one. https://pubmed.ncbi.nlm.nih.gov/ https://pubmed.ncbi.nlm.nih.gov/
      - foobarchu 2y ago
        This thread has multiple people relating their personal stories of using ozempic to start building those healthy habits. Also, it doesn't just magically get rid of fat so you can eat more, its supposed to make you feel full longer (as I understand it, someone feel free to correct me on that). Plus, even if it did magically get rid of fat temporarily, I'd rather encourage people to do something rather than simply shaming them for giving into a very human addiction. Your biggest concern around glp-1 drugs shouldn't be the overweight people successfully slimming down, it should be people who are already a healthy enough weight who think they need to be even skinnier (something I've encountered plenty of).
  - BurningFrog 2y ago
    I guess young people don't always know this, but there are plenty of medications a lot of people take for the rest of their lives. Blood pressure and cholesterol pills are maybe the most common. This gives a vast number of people 5-10 years longer lives, and I think this is great thing, even if some pharma executives end up getting rich.
    - Karrot_Kream 2y ago
      Not just young people. High blood pressure runs in our family. A cousin, despite being healthy in most indicators, developed high blood pressure at 23. She's still going in her 50s just fine but has had to take blood pressure meds for the last 27 years.
    - ido 2y ago
      Or insulin. I’ve been shortsighted since childhood and will need to wear glasses for the rest of my life (unless I get laser corrective surgery, I guess). Many people in my wife’s family have thyroid gland dysfunction and have to take thyroid hormones their whole lives.
  - Tagbert 2y ago
    I take a statin as something in my body produces high levels of cholesterol even on a low fat diet. I will always take a statin. It works well and there are few side effects. My spouse must take a thyroid medicine every day for life. Not taking these pills is life threatening. How is taking them not acceptable?
  - lazyasciiart 2y ago
    Wait til you learn about hormonal birth control.
  - golol 2y ago
    Why not? What would you rather be: Fat to your death, or healthy and dependent on modern technological society in yet another way? How is it any different to diabetes treatment?
s1artibartfast 2y ago
Some regain, some don't. Some people have multiple heart attacks. It is really that simple.

JamesBarney 2y ago

Sorry I meant with continued use of the treatment you don't regain the weight. I agree if you stop taking the medication your weight will rebound.

Alupis 2y ago
Right, so we doom some portion of the population to forever take a pill from big pharma? How is that acceptable with anyone? The goal should be to use Ozempic until you are in a better place to manage things yourself. The goal should not be to get people hooked on Ozempic for their entire lives. Perhaps Ozempic prescriptions should come with prescribed exercise with check-in and monitoring, or something.
- rootusrootus 2y ago
  > doom some portion of the population to forever take a pill from big pharma That is temporary. The effects are real. The fact that you don't think big pharma should profit handsomely for making it happen is not the only alternative. Before too long semaglutide, as one example, will be out of patent and available as a generic. It won't cost a thousand bucks a month to big pharma, it'll be practically free. Cheap enough that most insurance plans will likely subsidize it all the way to zero out-of-pocket cost just because the ROI is so good.
- fragmede 2y ago
  How my decisions will affect some company's bottom line is way behind "will this help me live a better, longer life" in my list of priorities, but I'm already on other medications that are generic for the rest of my life for other genetic defects I've been blessed with, though I'm not on Ozempic.
- JamesBarney 2y ago
  > Right, so we doom some portion of the population to forever take a pill from big pharma? How is that acceptable with anyone This is literally how almost all medicine works that treats a chronic condition. > Perhaps Ozempic prescriptions should come with prescribed exercise with check-in and monitoring, or something. Why?
  - formerly_proven 2y ago
    [flagged]
    - tomrod 2y ago
      We don't get pissed that elephants don't climb trees. What value is it to characterize people's obesity entirely as slovenness and gluttony? While there are certainly some slobs and glutton, dismissive judgmentality of everyone doesn't make sense. For this reason, I believe your comment is lacking in empathy for people who may struggle differently than you, yet struggle all the same.
    - JamesBarney 2y ago
      Sure of the almost 8 billion people in the world there are plenty who have successfully lost and kept off weight. But if you want to see if there is a reproduceable lifestyle intervention that treats obesity successfully in the long term you can look here. After a few hours of searching you will probably find the same thing I and almost all obesity researchers have concluded. There isn't one. https://pubmed.ncbi.nlm.nih.gov/ https://pubmed.ncbi.nlm.nih.gov/
    - foobarchu 2y ago
      This thread has multiple people relating their personal stories of using ozempic to start building those healthy habits. Also, it doesn't just magically get rid of fat so you can eat more, its supposed to make you feel full longer (as I understand it, someone feel free to correct me on that). Plus, even if it did magically get rid of fat temporarily, I'd rather encourage people to do something rather than simply shaming them for giving into a very human addiction. Your biggest concern around glp-1 drugs shouldn't be the overweight people successfully slimming down, it should be people who are already a healthy enough weight who think they need to be even skinnier (something I've encountered plenty of).
- BurningFrog 2y ago
  I guess young people don't always know this, but there are plenty of medications a lot of people take for the rest of their lives. Blood pressure and cholesterol pills are maybe the most common. This gives a vast number of people 5-10 years longer lives, and I think this is great thing, even if some pharma executives end up getting rich.
  - Karrot_Kream 2y ago
    Not just young people. High blood pressure runs in our family. A cousin, despite being healthy in most indicators, developed high blood pressure at 23. She's still going in her 50s just fine but has had to take blood pressure meds for the last 27 years.
  - ido 2y ago
    Or insulin. I’ve been shortsighted since childhood and will need to wear glasses for the rest of my life (unless I get laser corrective surgery, I guess). Many people in my wife’s family have thyroid gland dysfunction and have to take thyroid hormones their whole lives.
- Tagbert 2y ago
  I take a statin as something in my body produces high levels of cholesterol even on a low fat diet. I will always take a statin. It works well and there are few side effects. My spouse must take a thyroid medicine every day for life. Not taking these pills is life threatening. How is taking them not acceptable?
- lazyasciiart 2y ago
  Wait til you learn about hormonal birth control.
- golol 2y ago
  Why not? What would you rather be: Fat to your death, or healthy and dependent on modern technological society in yet another way? How is it any different to diabetes treatment?

s1artibartfast 2y ago

Some regain, some don't. Some people have multiple heart attacks. It is really that simple.