3 ms·

It's not the manic behavior, but the opposite. GLP-1 agonists appear to reduce the impulsive behavior.

abeppu 2y ago
Does anyone have references on any explanation, or even partial explanation, on why this might be the case? The published stuff I can find seems to be at the level of anecdata, scarcely better than "I know a guy who..." - What people talk about on social media: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10669484/ https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10669484/ - Some people made large "reckless" life choices: https://academic.oup.com/qjmed/advance-article-abstract/doi/10.1093/qjmed/hcae095/7665706 https://academic.oup.com/qjmed/advance-article-abstract/doi/...
- deleted 2y ago
  [deleted]
- cyberax 2y ago
  > Does anyone have references on any explanation, or even partial explanation, on why this might be the case? Not yet. The effect appears to be real, but it's too soon to tell: https://www.science.org/content/blog-post/ozempic-and-other-glp-1-drugs-more-people-realize https://www.science.org/content/blog-post/ozempic-and-other-... From my own anecdata, unnecessary impulsive eating probably reinforces the impulsive behavior. You start associating impulsive behavior with a reward. GLP-1 not only removes that, but adds a slight negative reinforcement. Impulsive eating no longer brings reward, but makes you feel over-full. This can then down-regulates the pathways that lead to increased impulsive behavior.
  - rootusrootus 2y ago
    Great description, thanks! I won't sugarcoat my problems. I knew I wasn't hungry when I'd eat sometimes. I knew it would keep me overweight. I knew it wouldn't even feel great afterwards. And yet, more often than not I did it. And beat myself up over it every time. Very demoralizing, even without help from moralizing folks on the internet. On tirzepatide the impulse is just gone. I feel like I can take it or leave it, and since the consequences of eating unnecessarily are quickly negative, I just don't do it.
- AlanYx 2y ago
  There are about a dozen published studies using GLP-1 analogues in animal models showing reduction in addictive behaviors (search for papers by Jerlhag, Leggio and Schmidt). The prevailing theory seems to relate to dopamine regulation.
Qem 2y ago
> GLP-1 agonists appear to reduce the impulsive behavior. Does it reduce sex drive as well?
- firesteelrain 2y ago
  No it doesn’t but some people have started TRT therapy too which will increase testosterone and then sex drive too
  - swat535 2y ago
    Doesn't losing weight already increases your Testostrone?.. people seriously shouldn't get on TRT unless they need it medically, once you start it, it's for life and also you will be infertile.. (source I am on HCG, an alternative to TRT due to its side effects).
    - firesteelrain 2y ago
      That's correct - you need to be seen by a doctor before embarking on TRT. For me, I have no intent of having any more kids. Infertile can be reversed.
- rootusrootus 2y ago
  TMI, but no.

Does anyone have references on any explanation, or even partial explanation, on why this might be the case? The published stuff I can find seems to be at the level of anecdata, scarcely better than "I know a guy who..." - What people talk about on social media: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10669484/ https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10669484/ - Some people made large "reckless" life choices: https://academic.oup.com/qjmed/advance-article-abstract/doi/10.1093/qjmed/hcae095/7665706 https://academic.oup.com/qjmed/advance-article-abstract/doi/...

deleted 2y ago
[deleted]
cyberax 2y ago
> Does anyone have references on any explanation, or even partial explanation, on why this might be the case? Not yet. The effect appears to be real, but it's too soon to tell: https://www.science.org/content/blog-post/ozempic-and-other-glp-1-drugs-more-people-realize https://www.science.org/content/blog-post/ozempic-and-other-... From my own anecdata, unnecessary impulsive eating probably reinforces the impulsive behavior. You start associating impulsive behavior with a reward. GLP-1 not only removes that, but adds a slight negative reinforcement. Impulsive eating no longer brings reward, but makes you feel over-full. This can then down-regulates the pathways that lead to increased impulsive behavior.
- rootusrootus 2y ago
  Great description, thanks! I won't sugarcoat my problems. I knew I wasn't hungry when I'd eat sometimes. I knew it would keep me overweight. I knew it wouldn't even feel great afterwards. And yet, more often than not I did it. And beat myself up over it every time. Very demoralizing, even without help from moralizing folks on the internet. On tirzepatide the impulse is just gone. I feel like I can take it or leave it, and since the consequences of eating unnecessarily are quickly negative, I just don't do it.
AlanYx 2y ago
There are about a dozen published studies using GLP-1 analogues in animal models showing reduction in addictive behaviors (search for papers by Jerlhag, Leggio and Schmidt). The prevailing theory seems to relate to dopamine regulation.

Qem 2y ago

> GLP-1 agonists appear to reduce the impulsive behavior. Does it reduce sex drive as well?

firesteelrain 2y ago
No it doesn’t but some people have started TRT therapy too which will increase testosterone and then sex drive too
- swat535 2y ago
  Doesn't losing weight already increases your Testostrone?.. people seriously shouldn't get on TRT unless they need it medically, once you start it, it's for life and also you will be infertile.. (source I am on HCG, an alternative to TRT due to its side effects).
  - firesteelrain 2y ago
    That's correct - you need to be seen by a doctor before embarking on TRT. For me, I have no intent of having any more kids. Infertile can be reversed.
rootusrootus 2y ago
TMI, but no.