3 ms·
Source? https://www.mcgill.ca/oss/article/medical-critical-thinking/berberine-dont-swallow-hype-or-pill https://www.mcgill.ca/oss/article/medical-critical-think
by wizzwizz4 2y ago
Source? https://www.mcgill.ca/oss/article/medical-critical-thinking/berberine-dont-swallow-hype-or-pill https://www.mcgill.ca/oss/article/medical-critical-thinking/... (2023) disagrees with you:
> Neither is berberine any version of Ozempic, which is an analogue of glucagon-like-peptide-1 (GLP-1), a natural hormone that regulates blood sugar and helps people feel full. Berberine has nothing to do with GLP-1.
> Perhaps the most interesting laboratory finding, given the rising global tide of type 2 diabetes, is the control that berberine may exert over blood sugar. But there is a problem. Berberine is virtually insoluble in water and has low intestinal absorption which means it has poor bioavailability. […] Because of berberine’s poor bioavailability, supplements on the market are likely to be useless. However, some derivative of berberine, may yet make it to the physician’s prescription pad. But it won’t be for weight loss.
- zonkerdonker 2y agoI was able to find this: https://www.sciencedirect.com/science/article/abs/pii/S0006295215003822#:~:text=The%20present%20results%20demonstrated%20that,taste%20substance%20obtain%20hypoglycemic%20effect https://www.sciencedirect.com/science/article/abs/pii/S00062.... Apparently most of the effect is due to activation of the "bitter taste reception pathways" in the gut. So even though it has very low bioavailibility, it can still stimulate GLP-1 secretion just simply due to its incredible bitterness
- rootusrootus 2y agoDoes it only stimulate GLP-1 in the gut, though? As I understand it, most of the positive effects of GLP-1 agonists are the effect they have on the brain's GLP-1 system, not the guts.