Living organisms have certain features that simulations don't, and in particular it is good to remember that whatever simulations we currently can run they are

Living organisms have certain features that simulations don't, and in particular it is good to remember that whatever simulations we currently can run they are actually but abstractions. Organisms are evolved to survive, reproduce their forms and structures in time, and be in a certain allostatic equilibrium state, and that gives them a certain purpose and that simulations lack. If we look at organisms only as information processors and disregard the coupling of their physiological states with their behaviour and with the environment we lose everything that makes life, life.