I've never heard of combining metformin with the other two drugs. The naltrexone/bupropion combination is sold under the brand name Contrave. As with any weight

I've never heard of combining metformin with the other two drugs. The naltrexone/bupropion combination is sold under the brand name Contrave. As with any weight loss drug, I recommend a healthy amount of scepticism. Contrave's history includes an initial FDA disapproval and two prematurely terminated studies, and the drug changed hands a couple of times. https://en.wikipedia.org/wiki/Naltrexone/bupropion#History https://en.wikipedia.org/wiki/Naltrexone/bupropion#History