3 ms·
It does feel like every organ system and every disease has at least one research group trying to connect it to the microbiome. It's reminiscent of the hype cycl
by Calavar 2y ago
It does feel like every organ system and every disease has at least one research group trying to connect it to the microbiome. It's reminiscent of the hype cycle around oxidative stress and antioxidants 20 uears ago. There was a core of solid science there, but in terms of connecting specific diseases to oxidative stress, it seems like the research community has largely moved on.
- FollowingTheDao 2y ago> in terms of connecting specific diseases to oxidative stress, it seems like the research community has largely moved on. As someone who knows someone at UNC Chapel Hill who was researching this starting about 15 years ago, the research community did not move on, the news just stopped talking/hyping about it. Here is a recent paper: Oxidative stress: The core pathogenesis and mechanism of Alzheimer's disease https://pubmed.ncbi.nlm.nih.gov/35395415/ https://pubmed.ncbi.nlm.nih.gov/35395415/ It is fundamentally true that oxidative balance is crucial to health, and that nutrients play a large role in maintaining that balance; Manganese (SOD2) zinc/copper (SOD1/SOD3), Selenium/Riboflavin/Pyridoxine (Glutathione). Deficiencies will not cause one disease, but many different ones, depending on the persons risk. I think oxidative balance plays a large role in controlling the microbiome. Nutrition, oxidative stress and intestinal dysbiosis: Influence of diet on gut microbiota in inflammatory bowel diseases https://pubmed.ncbi.nlm.nih.gov/35395415/ https://pubmed.ncbi.nlm.nih.gov/35395415/