3 ms·
Derek Lowe on this use of CAR-T: https://www.science.org/content/blog-post/car-t-autoimmune-disorders https://www.science.org/content/blog-post/car-t-autoimmune
by amluto 2y ago
Derek Lowe on this use of CAR-T: https://www.science.org/content/blog-post/car-t-autoimmune-disorders https://www.science.org/content/blog-post/car-t-autoimmune-d...
And on the apparent long term risks of CAR-T: https://www.science.org/content/blog-post/downside-car-t-therapy https://www.science.org/content/blog-post/downside-car-t-the...
- Loughla 2y agoSo the long term risks are mostly from secondary infection, and it's only half of the 5-11% of the cases of mortality after treatment. I think that sounds pretty fucking good considering the other option is definitely just being dead. That's as close to a miracle treatment as I believe we will get.
- amluto 2y agoIf you’re treating an otherwise-fatal cancer, sure, although it would still great to further improve the treatment. If you’re treating a much less lethal autoimmune condition, then the calculation is a bit different.