4 ms·

The article is useless because it says nothing about what the active ingredients are. The corresponding reference is also equally useless since it's paywalled.

The article is useless because it says nothing about what the active ingredients are. The corresponding reference is also equally useless since it's paywalled. Nothing to see here.

pessimizer 2y ago
You forgot the /s. Or at least I deeply hope you forgot the /s.
- OutOfHere 2y ago
  Why do you think so? Firstly, they have not publicly listed the ingredients. It's behind a paywall. Secondly, it's not even tested in humans. There is a fair chance of it being a scam.
sampo 2y ago
I think I found the preprint of the article. Of course, the final published article has gone through some further editing. Anyway: > To ensure safety during daily or repeated use, PCANS was meticulously designed as a “drug-free” formulation, incorporating biopolymers, surfactants, and alcohols that are listed in the inactive ingredient database (IID) or generally recognized as safe (GRAS) list of the Food and Drug Administration (FDA), and are present as excipients in commercially available nasal/topical formulations. These components and their unique concentrations were identified via a highly iterative approach aimed at maximizing sprayability, mucoadhesiveness, the capture of respiratory droplets, physical barrier property, pathogen neutralization activity, and nasal residence time. > To prepare PCANS, gellan and pectin solutions were mixed in a ratio of 1:1, followed by the addition of tween-80 (Sigma Aldrich). The solution was then supplemented with benzalkonium chloride (BKC) (Sigma Aldrich) and subjected to immediate mixing by pipetting up and down several times. Finally, phenethyl alcohol (Sigma Aldrich) was added, and the pH of the solution was adjusted to 5.5. https://www.biorxiv.org/content/10.1101/2023.10.02.560602v1.full https://www.biorxiv.org/content/10.1101/2023.10.02.560602v1....
- OutOfHere 2y ago
  They seem to already have a commercial product named "Profi" with these ingredients, although the fact that it hasn't been tested in humans makes me trust it less.

The article is useless because it says nothing about what the active ingredients are. The corresponding reference is also equally useless since it's paywalled. Nothing to see here.

pessimizer 2y ago

You forgot the /s. Or at least I deeply hope you forgot the /s.

OutOfHere 2y ago
Why do you think so? Firstly, they have not publicly listed the ingredients. It's behind a paywall. Secondly, it's not even tested in humans. There is a fair chance of it being a scam.

sampo 2y ago

I think I found the preprint of the article. Of course, the final published article has gone through some further editing. Anyway: > To ensure safety during daily or repeated use, PCANS was meticulously designed as a “drug-free” formulation, incorporating biopolymers, surfactants, and alcohols that are listed in the inactive ingredient database (IID) or generally recognized as safe (GRAS) list of the Food and Drug Administration (FDA), and are present as excipients in commercially available nasal/topical formulations. These components and their unique concentrations were identified via a highly iterative approach aimed at maximizing sprayability, mucoadhesiveness, the capture of respiratory droplets, physical barrier property, pathogen neutralization activity, and nasal residence time. > To prepare PCANS, gellan and pectin solutions were mixed in a ratio of 1:1, followed by the addition of tween-80 (Sigma Aldrich). The solution was then supplemented with benzalkonium chloride (BKC) (Sigma Aldrich) and subjected to immediate mixing by pipetting up and down several times. Finally, phenethyl alcohol (Sigma Aldrich) was added, and the pH of the solution was adjusted to 5.5. https://www.biorxiv.org/content/10.1101/2023.10.02.560602v1.full https://www.biorxiv.org/content/10.1101/2023.10.02.560602v1....

OutOfHere 2y ago
They seem to already have a commercial product named "Profi" with these ingredients, although the fact that it hasn't been tested in humans makes me trust it less.