You only need the system package manager to provide the non-Python dependencies of Python packages. I'd expect that those by and large are already packaged in D

You only need the system package manager to provide the non-Python dependencies of Python packages. I'd expect that those by and large are already packaged in Debian and elsewhere, perhaps with some exceptions among smalltime C (or Rust) projects that only exist to accelerate Python packages. > Also, do you place to force everyone to use chroot or containers to replace their virtual env systems to have variations on deps? Or maybe everybody should use nix? Nix is a good fit for this, but so is Guix and probably Spack. With a sane implementation of PEP-725 (which I mention and describe in another comment on this post), users could freely choose whatever package manager they like to supply non-Python deps.