> While the proponents of the “calories in / calories out” idea claim it's just thermodynamics It obviously is. > they use it as an argument to eat less. You

> While the proponents of the “calories in / calories out” idea claim it's just thermodynamics It obviously is. > they use it as an argument to eat less. You have evidence that _other_ things will also have an impact. Eating less does work regardless of your genetic makeup. There's decades of good evidence and plain observation that this is true. > Mouse data show clear interventional evidence that you can change the metabolic rate to change weight outcomes. I really wish people had a deeper understanding of how "mouse data" is actually generated. You don't find fat mice and put them on a diet as there is no study that can accommodate this. You make them fat intentionally and then you mess with them to measure outcomes. > I don’t expect these trials to pass IRB review, so you must go forward and be n=1. You might ask _why_ they wouldn't pass review first, and it's not because the IRB is interested in promulgating "bullshit."