3 ms·

Does this work to assess each individual'd actual caffeine half life? Every individual is metabolizing caffeine at a different rate...

4gotunameagain 2y ago
Line 6 of readme.md: Assumptions The script works on some generalized assumptions that would be difficult to take into account.
- shlant 2y ago
  why read anything when you can just ask the comments and make someone else do the work? /s
err4nt 2y ago
As long as you're consistent enough, if you use this tool for a while could you learn how to tune the value it gives you? E.g. if you know you need extra time, or less time you can take that into account when reading this.
danielbarla 2y ago
Indeed, and the variance on this number is surprisingly large. From [1]: > The mean half-life of caffeine in plasma of healthy individuals is about 5 hours. However, caffeine's elimination half-life may range between 1.5 and 9.5 hours, while the total plasma clearance rate for caffeine is estimated to be 0.078 L/h/kg (Brachtel and Richter, 1992; Busto et al., 1989). This wide range in the plasma mean half-life of caffeine is due to both innate individual variation, and a variety of physiological and environmental characteristics that influence caffeine metabolism (e.g., pregnancy, obesity, use of oral contraceptives, smoking, altitude). On the one end of the scale, it'd be nigh-undetectable within a few hours, and on the other end, significantly present for 24 hours+. I suspect estimating this number is also fairly difficult. I mean, I have some idea of the _outcome_ of what happens if I drink coffee at say 6PM, but I have little way of reversing this into a half-life number. [1] - https://www.ncbi.nlm.nih.gov/books/NBK223808/ https://www.ncbi.nlm.nih.gov/books/NBK223808/
reportgunner 2y ago
I think it's just a cool toy for people who think coffee is cool, I don't feel like it's supposed to be accurate.

4gotunameagain 2y ago

Line 6 of readme.md: Assumptions The script works on some generalized assumptions that would be difficult to take into account.

shlant 2y ago
why read anything when you can just ask the comments and make someone else do the work? /s

err4nt 2y ago

As long as you're consistent enough, if you use this tool for a while could you learn how to tune the value it gives you? E.g. if you know you need extra time, or less time you can take that into account when reading this.

danielbarla 2y ago

Indeed, and the variance on this number is surprisingly large. From [1]: > The mean half-life of caffeine in plasma of healthy individuals is about 5 hours. However, caffeine's elimination half-life may range between 1.5 and 9.5 hours, while the total plasma clearance rate for caffeine is estimated to be 0.078 L/h/kg (Brachtel and Richter, 1992; Busto et al., 1989). This wide range in the plasma mean half-life of caffeine is due to both innate individual variation, and a variety of physiological and environmental characteristics that influence caffeine metabolism (e.g., pregnancy, obesity, use of oral contraceptives, smoking, altitude). On the one end of the scale, it'd be nigh-undetectable within a few hours, and on the other end, significantly present for 24 hours+. I suspect estimating this number is also fairly difficult. I mean, I have some idea of the _outcome_ of what happens if I drink coffee at say 6PM, but I have little way of reversing this into a half-life number. [1] - https://www.ncbi.nlm.nih.gov/books/NBK223808/ https://www.ncbi.nlm.nih.gov/books/NBK223808/

reportgunner 2y ago

I think it's just a cool toy for people who think coffee is cool, I don't feel like it's supposed to be accurate.