Cool. I have a Partial PNP Deficiency that makes it harder for me to break down Inosine and Guanosine (and xanthine). My PNP enzyme only functions at about 12%

Cool. I have a Partial PNP Deficiency that makes it harder for me to break down Inosine and Guanosine (and xanthine). My PNP enzyme only functions at about 12% of most "normal" people. Image: https://www.frontiersin.org/files/Articles/538247/fimmu-11-01257-HTML/image_m/fimmu-11-01257-g001.jpg https://www.frontiersin.org/files/Articles/538247/fimmu-11-0... Paper on the topic: https://www.frontiersin.org/journals/immunology/articles/10.3389/fimmu.2020.01257/full https://www.frontiersin.org/journals/immunology/articles/10.... So how does food affect me? They use Inosine (Inosinic acid) and Guanosine (Guanylic acid) in foods as a food additives to increase the umami. https://www.eurofins.com/media-centre/newsletters/food-newsletter-nr44-march-2014/flavour-enhancers-in-food-products/ https://www.eurofins.com/media-centre/newsletters/food-newsl... These are also found naturally in many foods: https://www.umamiinfo.com/richfood/ https://www.umamiinfo.com/richfood/ When I eat these foods I cannot break these purines down and they not only cause mood issues but also an immune deficiency. Purinergic System Dysfunction is linked to mood disorders: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4262688/ https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4262688/ After going on a low specific purine diet I no longer need any of the three psychiatric medications I was on but for klonopin since there are some triggers I cannot avoid. Food did this. Food and having a good doctor who did not give up on me. Food and knowing what my genetics are. I get that some people might benefit from Yoga, etc, but to serve a blanket statement like that is just ignorant of the genetic and environmental diversity of humanity. I have these genetics because I have Sami heritage and I am adapted to live in a cold climate and eating low purine, high zinc foods. Zinc also helps me break down the purines by stimulating LACC1, which is a sort of PNP backup. A zinc deficiency when I was young left me with an undecended testicle because of my LACC1 genetics. https://www.uniprot.org/uniprotkb/Q8IV20/entry https://www.uniprot.org/uniprotkb/Q8IV20/entry