3 ms·

I'm always open to learning things I don't know about ... go on

FollowingTheDao 2y ago
Cool. I have a Partial PNP Deficiency that makes it harder for me to break down Inosine and Guanosine (and xanthine). My PNP enzyme only functions at about 12% of most "normal" people. Image: https://www.frontiersin.org/files/Articles/538247/fimmu-11-01257-HTML/image_m/fimmu-11-01257-g001.jpg https://www.frontiersin.org/files/Articles/538247/fimmu-11-0... Paper on the topic: https://www.frontiersin.org/journals/immunology/articles/10.3389/fimmu.2020.01257/full https://www.frontiersin.org/journals/immunology/articles/10.... So how does food affect me? They use Inosine (Inosinic acid) and Guanosine (Guanylic acid) in foods as a food additives to increase the umami. https://www.eurofins.com/media-centre/newsletters/food-newsletter-nr44-march-2014/flavour-enhancers-in-food-products/ https://www.eurofins.com/media-centre/newsletters/food-newsl... These are also found naturally in many foods: https://www.umamiinfo.com/richfood/ https://www.umamiinfo.com/richfood/ When I eat these foods I cannot break these purines down and they not only cause mood issues but also an immune deficiency. Purinergic System Dysfunction is linked to mood disorders: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4262688/ https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4262688/ After going on a low specific purine diet I no longer need any of the three psychiatric medications I was on but for klonopin since there are some triggers I cannot avoid. Food did this. Food and having a good doctor who did not give up on me. Food and knowing what my genetics are. I get that some people might benefit from Yoga, etc, but to serve a blanket statement like that is just ignorant of the genetic and environmental diversity of humanity. I have these genetics because I have Sami heritage and I am adapted to live in a cold climate and eating low purine, high zinc foods. Zinc also helps me break down the purines by stimulating LACC1, which is a sort of PNP backup. A zinc deficiency when I was young left me with an undecended testicle because of my LACC1 genetics. https://www.uniprot.org/uniprotkb/Q8IV20/entry https://www.uniprot.org/uniprotkb/Q8IV20/entry
- seper8 2y ago
  Super interesting, thanks for sharing
- jaggederest 2y ago
  Thank you for posting the genetic polymorphism, makes it much easier to cross reference. Glad you've found an answer!
- dukeofdoom 2y ago
  Thank you, interesting read. My friend that has an autistic son, wants to cure him through diet changes. Do you know anything food related to autism?
  - FollowingTheDao 2y ago
    Not really, but this may be a good start: Purine signaling pathway dysfunction in autism spectrum disorders: Evidence from multiple omics data https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9935591/ https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9935591/ and https://www.mdpi.com/2218-1989/10/5/184 https://www.mdpi.com/2218-1989/10/5/184 I do not think the spectrum of autism are caused by a single gene or environmental factor. I was diagnosed with Asperger's as well, much too late in life.

Cool. I have a Partial PNP Deficiency that makes it harder for me to break down Inosine and Guanosine (and xanthine). My PNP enzyme only functions at about 12% of most "normal" people. Image: https://www.frontiersin.org/files/Articles/538247/fimmu-11-01257-HTML/image_m/fimmu-11-01257-g001.jpg https://www.frontiersin.org/files/Articles/538247/fimmu-11-0... Paper on the topic: https://www.frontiersin.org/journals/immunology/articles/10.3389/fimmu.2020.01257/full https://www.frontiersin.org/journals/immunology/articles/10.... So how does food affect me? They use Inosine (Inosinic acid) and Guanosine (Guanylic acid) in foods as a food additives to increase the umami. https://www.eurofins.com/media-centre/newsletters/food-newsletter-nr44-march-2014/flavour-enhancers-in-food-products/ https://www.eurofins.com/media-centre/newsletters/food-newsl... These are also found naturally in many foods: https://www.umamiinfo.com/richfood/ https://www.umamiinfo.com/richfood/ When I eat these foods I cannot break these purines down and they not only cause mood issues but also an immune deficiency. Purinergic System Dysfunction is linked to mood disorders: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4262688/ https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4262688/ After going on a low specific purine diet I no longer need any of the three psychiatric medications I was on but for klonopin since there are some triggers I cannot avoid. Food did this. Food and having a good doctor who did not give up on me. Food and knowing what my genetics are. I get that some people might benefit from Yoga, etc, but to serve a blanket statement like that is just ignorant of the genetic and environmental diversity of humanity. I have these genetics because I have Sami heritage and I am adapted to live in a cold climate and eating low purine, high zinc foods. Zinc also helps me break down the purines by stimulating LACC1, which is a sort of PNP backup. A zinc deficiency when I was young left me with an undecended testicle because of my LACC1 genetics. https://www.uniprot.org/uniprotkb/Q8IV20/entry https://www.uniprot.org/uniprotkb/Q8IV20/entry

seper8 2y ago
Super interesting, thanks for sharing
jaggederest 2y ago
Thank you for posting the genetic polymorphism, makes it much easier to cross reference. Glad you've found an answer!
dukeofdoom 2y ago
Thank you, interesting read. My friend that has an autistic son, wants to cure him through diet changes. Do you know anything food related to autism?
- FollowingTheDao 2y ago
  Not really, but this may be a good start: Purine signaling pathway dysfunction in autism spectrum disorders: Evidence from multiple omics data https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9935591/ https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9935591/ and https://www.mdpi.com/2218-1989/10/5/184 https://www.mdpi.com/2218-1989/10/5/184 I do not think the spectrum of autism are caused by a single gene or environmental factor. I was diagnosed with Asperger's as well, much too late in life.