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Omega 3 supplements are such a wild world. So many low quality ones, so many different types, and so many claims about them being miracle cures (that then don't
by Trasmatta 2y ago
Omega 3 supplements are such a wild world. So many low quality ones, so many different types, and so many claims about them being miracle cures (that then don't hold out for later studies).
I have severe chronic dry eye, and omega 3 is one of the first things they recommend. But then in the past 5 or 6 years there have been a bunch of studies that have shown there is no actual measurable effect.
Some people still claim that it helps, but that you have to get it by actually eating Omega 3 rich fish, and not just taking the supplements. Either way, I've never seen any difference with my dry eye symptoms.
- oidar 2y agoI have dry eye as well. What have you done that helps? Omega 3 didn’t do anything for me either.
- nanna 2y agoI had agonising pain from dry eyes when I woke up. It felt like my lense was scratched, but it wasn't. An eye specialist told me that in fact my eyelid pores were bunged up and weren't release enough moisture at night. A predisposition that years at the screen not blinking enough made accute. He advised eyelid wipes morning and night and it cleared the issue. he told me that instead of eyelid wipes, to keep the costs down, I could use bicarbonate of soda (medical grade) boiled in water (about a teaspoon to 500ml I think, and then just dip qtips into it (cooled of course). Keep that mix in the fridge for no longer than a week before making a new batch.
- oidar 2y agoI have a nearly identical issue. Do you recall the diagnosis? Also, when you do the wipes how "deep" do you go when wiping the lids?
- nanna 2y agoSorry to hear that. I forget exactly the diagnosis but maybe it was meibomian gland dysfunction and/or blepharitis? How deep? Basically with one hand pull your eyelid up or down (depending on which one) and then while keeping your eye open, which I find quite hard, wipe along the pink line of the eyelid with the eyelid wipe backwards and forwards ten times. It has to be along this line as that's where the glands are. Do this for both top and bottom eyelid. If it's really bad like mine was you might need to take some medication - I was put on steroids I think. Sorry memory not serving me hugely well here but good luck! I'll check for comments in case this wasn't clear enough.
- FollowingTheDao 2y agoI have uveitis and it certainly helped for me. I think what happens is a lot of people don’t lower the amount omega 6 and just increase omega-3 by a small amount. It took a drastic reduction in omega 6 for it to help.
- Trasmatta 2y agoI'm about 10 years into this, and I've tried many many things. It's all about management now. It really depends on the type of dry eye you have, so I'd recommend seeing a dry eye specialist if you haven't. Getting a meibography done is really important for seeing the state of your glands. The things that work the best for me currently are Systane Hydration PF eye drops, NuLids, Manuka Honey gel, OcuSoft lid scrubs, moving out of a dry climate, and limiting screen time. Inflammation in general causes it to flare up -- diet, lack of sleep, alcohol, stress, staying up late coding or gaming, all seem to cause inflammation and make it worse for me. I've also done Restasis, Xiidra, Cequa, IPL, Radio Frequency, warm compresses, and punctal plugs, without much success. I'd like to try autologous tear serum next.
- calf 2y agoI'm doing IPL/RF now which is theorized to help with inflammation, but now I know to be more careful with healthy lifestyle. Too bad this understanding of computer lifestyle and dry eye syndrome was that well explained and emphasizsd 15 years ago.
- Trasmatta 2y agoHave you noticed any improvement with IPL/RF? I've done 5 sessions - I saw improvement after the first and fourth, but regressed pretty quicky back after a few days. I've heard some people saying they had to do like 10 to start to notice a bigger difference. The problem is it's so expensive (I have to pay $750 for the combo session).
- youniverse 2y agoWow you've tried the whole industry. The only thing I can recommend to you would be to try a brand of drops called Optase, they are more quality and thicker than everything else on the market. Here's a HN post with a really good top comment that talks about psychological eye strain that really resonated with me, plenty of other advice in there too you might like: https://news.ycombinator.com/item?id=34518343 https://news.ycombinator.com/item?id=34518343 Good luck!
- sebmellen 2y agoFor me, Xiidra combined with once a day Pataday (which actually dries the eye, but for me helped stem inflammation that was harming my ability to form a tear film), plus this iTEAR device (https://olympicophthalmics.com/itear-100/ https://olympicophthalmics.com/itear-100/), was incredibly helpful. I’d also recommend getting a humidifier for each of your main rooms and using distilled water with it.
- cyberax 2y agoPerfluorohexyloctane helped me quite a bit. You can ship it from Europe for something like $20 per vial (EvoTears), or get in the US for $700 (Miebo). The vials are literally identical.
- amluto 2y agoNifty but perhaps distressing. A brief search found nothing about what happens to it after you put it in your eyes. I assume a bunch of it ends up in your tear ducts, to your nose, and into your stomach. And then?
- cyberax 2y agoIt'll diffuse out eventually. It's metabolically inert, and it's been used as a vitreous humor substitute for quite a while.
- 93po 2y agoI cured mine bc I figured out it was related to LPR/reflux which was causing dry eyes along with some other crappy stuff.
- cbruns 2y agoWhat was the cure?
- 93po 2y agoLPR is really tricky because weeks of "good behavior" can be undone very easily with one wrong move. It also took me years to figure out it was LPR because it doesn't have traditional acid reflux symptoms and can also look a lot like allergies or other things my doctors labeled it with instead. For me it was especially debilitating because it inflamed my Eustachian tubes, which meant my middle ears filled with way too much fluid, and i'd have 5+ hour long vertigo attacks where i literally could not move a single inch and was vomiting the entire time and sometimes only had a few minutes of warning before this started. if this happened in public, which it thankfully never did in a way i couldn't get home or to my car quickly (to pass out in the back seat and barf out the window), it would have been absolutely awful. the other shitty symptom as i said was extremely dry eyes, like painfully dry, which i think was actually more just them stinging which feels identical to dry. no amount of eye drops helped, and i tried like 6 different types. anyway lots of tips online for LPR that are true for me: * nothing carbonated. this is one of the worst things i can do * nothing acidic. some fruit juices like pineapple in particular are really, really bad for me. coffee, even with milk and ice and sugar, is also really bad for me. overly acidic foods (vinegar, tomato based stuff, etc) are also bad. * anything spicy is really bad too * no caffeine * stopping eating before i feel full. this is hard for me because i've been a "eat until i'm stuffed" person my entire life and it's really satisfying for me to do so. * stopping drinking helps but i got symptoms to go away pretty well even with moderate+ levels of drinking. but mostly just sticking to liquor and no cocktails or beer or seltzers. wine seems okay. * sitting upright after eating for at least an hour or two * not eating for at least a few hours before bed * exercise helps a bit but isn't critical for me * daily allergy pill and nasal spray, even missing one day sucks dry eyes are my first symptom that i did something "wrong". once i learned to listen to that it helped a ton. if i do "wrong" things for like a week straight, the constant dizziness starts, and if i go on much further than that then the vertigo attacks start.
- faustlast 2y agoDo you get headaches because of your dry eyes? (specifically, after staring at screens for a long time)
- Trasmatta 2y agoI generally don't get headaches luckily. When my dry eye was a lot more severe I had to strain to see the screen, and would sometimes get them then. It's better managed now (but still severe).
- theropost 2y agoBlepharitis perhaps?
- AlisdairO 2y agoI used to (and I didn't find much relief from eye drops). For the headaches, turned out they were migraines, which I was getting from screwing up my face because my eyes were uncomfortable.
- someothherguyy 2y agoIt is suspect to me that a lot of waste products end up being pushed as supplements. Also, there is a swath of junk science associated with nutrition publishing.
- lambdaba 2y agoIt's used in TBI, see Dr. Barry Sears for some accounts. "Fish oil helped save our son" https://edition.cnn.com/2012/10/19/health/fish-oil-brain-injuries/index.html https://edition.cnn.com/2012/10/19/health/fish-oil-brain-inj... > Most of the studies about omega-3 for traumatic brain injury are in animals, but they indicate potential for healing the human brain. > After a trauma, the brain tends to swell, and the connections between some nerve cells can become damaged, while other cells simply die. > National Institutes of Health research suggests that omega-3 fatty acids may inhibit cell death and could be instrumental for reconnecting damaged neurons. > Another recent study revealed genes that are activated to contain massive damage – especially inflammation – when the brain is injured. What activates those genes: omega-3. > “We have strong data that suggest omega-3 will activate good proteins to cope with brain damage and turn off proteins that cause neuroinflammation,” said Dr. Nicolas Bazan, director of the Neuroscience Center of Excellence at LSU Health in New Orleans and author of the study. > Bailes consulted with a fish oil expert and eventually decided that administering 20 grams a day of omega-3 fish oil through a feeding tube might repair the myelin sheath. (For comparison: A typical supplemental dose for someone with an uninjured brain is about 2 grams a day.)
- hirvi74 2y agoTBI is a wide spectrum of conditions akin to "trauma" in psychological terms. I skimmed the article, but I didn't see any specific medical terms used. The reason I am curious is because I do not think that mTBI like concussions cause brain swelling since the injury is more of a functional injury than a structural injury. I like to play ice hockey as an adult, and I try to do everything reasonably possible to protect my brain from vulcanized rubber disks flying at my head at 0 < x 100 mph. Perhaps I will add some fish oil back into my diet. I already uses Lion's Mane, but I am not sure if it truly does anything, but I love the taste of the product I use, so I will continue to use it regardless. Not sure if I have ever had a "real" concussion, but definitely some ringers.
- FollowingTheDao 2y ago> Omega 3 supplements are such a wild world. That's why you should get it from seafood and grass fed mammals (if you need long chain PUFAs) or flaxseed (if you need short chain PUFAs). There are probably many other things in seafood that co-exist with Omega 3 for a reason.
- lambdaba 2y agoI've researched trustworthy brands a lot, the ones I settled on are Nootropics Depot, Viva Naturals and Nordic Naturals. I prefer those with only Vit E as preservative.
- AbstractH24 2y agoWhat led you to settle on these?
- lambdaba 2y ago- Nootropics Depot because I know the owner (online) and they do rigorous testing - Viva Naturals from recommendations and testing (Labdoor) - Nordic Naturals is a well-known premium brand frankly I haven't documented, these are just some things out of the top my head
- tharmas 2y agoHave you tried Lutein?
- l5870uoo9y 2y agoAnother important aspect regarding supplements; so few are tested for how well they are absorbed by human digestion.
- 2OEH8eoCRo0 2y agoIt's amazing the lengths some people will go to avoid eating fish.
- naitgacem 2y agoFish can be prohibitively expensive even in parts of the world with access to large amounts of seashorres. Think: North Africa.
- 2OEH8eoCRo0 2y agoI'm not talking to them I'm on HN with a buncha rich nerds looking for supplements.
- wezdog1 2y agoWhy is that amazing. Why not get it from the source. Algae
- Beijinger 2y agoI think there is a Russian medicine for dry eye: Visomitin But I remember a study that claimed it does not work. Also, may be currently hard to get.
- ahallock 2y agoThere are conflicting studies, but recently, it was determined you need adequate vitamin B levels to support omega-3. As an aside, you can definitely over-dose on omega-3 which can cause afib, and increase your chance of stroke. I was taking 2 grams per day and definitely had arrhythmia issues. Decreasing the dosage to 500mg per day eliminated the arrhythmia.
- dmix 2y agoDidn’t know that was possible with Omega 3. The pills I have are 660mg and recommends 1 per day, seems you took about 3.5x that dose By the way, how can you detect arrhythmia? Blood pressure monitor or Apple Watch? General feeling?
- salad-tycoon 2y agoYou can use an Apple Watch and it might eventually catch it or if you have pulse oximeter you can watch the pulse wave or you can just feel for it at your wrist, carotid neck, or left peck. You want a steady beat, you can tell if there is a pause. Probably the best way, other than a medical Holter monitor that you wear and a cardiologist reviews, would be to buy a chest strap that can independently record and you can review the rhythm. Look up PVC, PAC EKG. Some premature contractions are normal. Nothing to go off on a tangent if you catch one in blue moon. All that said, you will probably just feel a small kick in the chest and the above is unnecessary. Some people tend to anxiously get into these things without reason but the above can help with gathering evidence for your doctor if you suspect a problem that doesn’t go away with stopping supplements or coffee or booze etc. as sometimes heart things can be transient and hard to catch out of the moment. Palpitations can be caused by A LOT of things, I’ve noticed them from coq10, but there are so many other possibilities that it’s not necessarily something you want to self hack if you really do have a problem.
- naasking 2y agoPeople can often feel arrhythmia. It can feel like heart fluttering, or skipping a beat, like when you get startled. Depends on the type of arrhythmia too.
- zmmmmm 2y agoThe elephant in the room is that true randomised controlled trials take decades to do and even then are almost impossible to build in a way that teases out nuances such as the specific effects of individual compounds within a supplement. So we are effectively left with pseudoscience as the only other option, but what would you rather do - sacrifice all of the insight and knowledge we are learning at such a rapid pace in medicine today, just because there's no feasible way to prove it within your lifetime (like, if you wait 20 years for observational studies to show that humans benefit from Omega 3 you will have missed the entire window when it would have been beneficial). We have to find a balance, but it can't sit at the extreme of requiring everything to meet an impossible bar of scientific proof before we start to benefit from it. But the price to pay is that some of them are not going to pan out.
- wafflemaker 2y agoYour dry eye condition is probably way too severe for this to help, but here is a method that helps my eyes stay more healthy the more I stare into the PC screen: Eye exercises! Eye tissue is very suspectable to drying and eyes are fed with only one small artery. This makes simple exercises super effective! To enforce a routine I use 'safeeyes' on Linux. A mac alternative is EyeLeo (haven't tested). If you have a windows one, please share! I change settings to have a break every 10 minutes for 15 seconds. Today I'll add a new exercise to do the focus shifting exercise¹, because your dry eye scared me. It's funny, but in the weeks when I'm not using PC and don't remember to exercise eyes without prompting, I can feel my eyesight degrading and my eyes hurt. P.S. if you've never trained your eyes, it will hurt the first few time, but it's the good pain, like from stretching. Don't overdo anyway! ¹ focus shifting exercise - taken from Huberman Lab episode on eyesight and preventing myopia: you put a thumb in front of your eyes and focus on it. Then you slowly extend your arm forward, keeping the focus on it. After your arm is stretched, you switch focus to something as close to you as your extended arm and slowly move to different objects (or trace a wall or ground), changing objects when required, until you reach horizon (or furthest possible point). Then you trace back and end up moving your thumb towards your face again. One very good exercise that is missing from safeeyes.
- youniverse 2y agoEyeleo seems to be for windows only. If anyone is interested: http://eyeleo.com/ http://eyeleo.com/