3 ms·

But isn't one of the effects of GLP-1 is that it literally makes you not crave junk food? It doesn't just metabolize food more, or however that works, it also c

by calmoo 2y ago

But isn't one of the effects of GLP-1 is that it literally makes you not crave junk food? It doesn't just metabolize food more, or however that works, it also changes your dietary behaviours.

borski 2y ago
Not in the way you're implying. I should mention that I'm in a clinical trial for CagriSema (and it's a head-to-head efficacy trial against tirzepatide, so not blind, with no placebo, but randomized), so I am speaking from experience. It works in a few ways, but the vast majority of the benefit is just from delayed gastric emptying (food sticks around in you longer) which makes you feel fuller, and it helps remove hunger in general. If you're not careful, you'll find yourself simply not eating, so you have to be careful - that's a lot of why it leads to nausea. People don't eat, don't hydrate, and they get sick. Turns out that happens with or without the drug; not eating and not drinking will make you nauseous. If you have a bag of french fries, you will find yourself sick because you overdid it. It doesn't make them taste any less good. You just learn about portion control somewhat through force, because when you screw it up you feel ill. The other thing it does is remove the "food noise" so many of us simply exist with. I didn't know this was a thing, but it is - I grew up very impoverished, and we didn't always have food. I am also genetically predisposed to retaining more weight than necessary. Looking back now, I was constantly seeking a next snack or a next meal, almost before I finished my previous one, subconsciously. My days were split, in my head, into mealtimes and the times between mealtimes, which were usually snacking time. But between the habit, the ADHD, and the predisposition to always be thinking about it, it was an impossible habit to break. I didn't realize this until talking to my wife, who doesn't have this problem. She also didn't used to think every food tasted incredible. Just some. Meanwhile, there was almost nothing I ate that didn't taste fantastic, in my brain. That has also adjusted to be more "normal," but historically whenever my mom has stopped, that adjustment didn't revert. It would appear to have been stable, as it helps your brain and body simply figure out it isn't starving all the time. It's kind of hard to explain, so I hope that made sense.
- calmoo 2y ago
  Thanks for sharing your experience, very interesting!

by calmoo 2y ago

But isn't one of the effects of GLP-1 is that it literally makes you not crave junk food? It doesn't just metabolize food more, or however that works, it also changes your dietary behaviours.

borski 2y ago

Not in the way you're implying. I should mention that I'm in a clinical trial for CagriSema (and it's a head-to-head efficacy trial against tirzepatide, so not blind, with no placebo, but randomized), so I am speaking from experience. It works in a few ways, but the vast majority of the benefit is just from delayed gastric emptying (food sticks around in you longer) which makes you feel fuller, and it helps remove hunger in general. If you're not careful, you'll find yourself simply not eating, so you have to be careful - that's a lot of why it leads to nausea. People don't eat, don't hydrate, and they get sick. Turns out that happens with or without the drug; not eating and not drinking will make you nauseous. If you have a bag of french fries, you will find yourself sick because you overdid it. It doesn't make them taste any less good. You just learn about portion control somewhat through force, because when you screw it up you feel ill. The other thing it does is remove the "food noise" so many of us simply exist with. I didn't know this was a thing, but it is - I grew up very impoverished, and we didn't always have food. I am also genetically predisposed to retaining more weight than necessary. Looking back now, I was constantly seeking a next snack or a next meal, almost before I finished my previous one, subconsciously. My days were split, in my head, into mealtimes and the times between mealtimes, which were usually snacking time. But between the habit, the ADHD, and the predisposition to always be thinking about it, it was an impossible habit to break. I didn't realize this until talking to my wife, who doesn't have this problem. She also didn't used to think every food tasted incredible. Just some. Meanwhile, there was almost nothing I ate that didn't taste fantastic, in my brain. That has also adjusted to be more "normal," but historically whenever my mom has stopped, that adjustment didn't revert. It would appear to have been stable, as it helps your brain and body simply figure out it isn't starving all the time. It's kind of hard to explain, so I hope that made sense.

calmoo 2y ago
Thanks for sharing your experience, very interesting!