I was thinking OP meant more simulate as in https://en.wikipedia.org/wiki/OpenWorm https://en.wikipedia.org/wiki/OpenWorm ie. a complete bottom-up simulation at

I was thinking OP meant more simulate as in https://en.wikipedia.org/wiki/OpenWorm https://en.wikipedia.org/wiki/OpenWorm ie. a complete bottom-up simulation at the cellular level By your definition of simulate, I think artificial neural networks are absolutely on their way to simulate intelligence