3 ms·
Do you have a sense of how different mTOR-related interventions stack up? As in, metformin vs rapamycin vs intermittent fasting?
by sctb 2y ago
Do you have a sense of how different mTOR-related interventions stack up? As in, metformin vs rapamycin vs intermittent fasting?
- robwwilliams 2y agoRapamycin and related rapalogs will be far better than metformin at inhibiting mTORC1, and at a low and intermittent dose of 4-6 mg ONCE per week are quite safe. Best paper I know of now is Kaeberlein et al 2023: https://pubmed.ncbi.nlm.nih.gov/37191826/ https://pubmed.ncbi.nlm.nih.gov/37191826/
- fellowniusmonk 2y agoWhat about stuff like Berberine? Is that all smoke and mirror? It's always hard to tell if the research around "traditional" compounds is actually legit or just other countries engaging in what is effectively marketing.
- robwwilliams 2y agoWikipedia link on berberine makes good sense. No strong support yet. https://en.wikipedia.org/wiki/Berberine https://en.wikipedia.org/wiki/Berberine