4 ms·

Interesting work. There are also clinical trials, recent and ongoing, looking at the effects of metformin on aging in humans, too, including the TAME trial[0].

Interesting work. There are also clinical trials, recent and ongoing, looking at the effects of metformin on aging in humans, too, including the TAME trial[0]. [0]: https://www.afar.org/tame-trial https://www.afar.org/tame-trial

matthewdgreen 2y ago
For those who can't access the article, the dosage they used was 20mg/kg per day. The pills I've seen are 500mg, so for me that works out to 3-4 pills per day. I know some people who already take doses like that for high blood sugar with no ill effects, but some also do have ill effects. Also I am not a monkey, so no idea if this would be a great idea to try. I couldn't find the exact doses TAME is using, but some writeups point out that there's no effect on glucose levels beyond about 1,600mg per day.
- thehappypm 2y ago
  > Also I am not a monkey [Citation Needed]
- leptons 2y ago
  I've been taking 2000mg of metformin every day for years, no ill effects. I guess I'm one of the lucky ones? Also, I'm a type of monkey more commonly referred to as "human".
  - snailb 2y ago
    Same here, 2kmg every day split between 1 in the morning and one in the evening. I did have Diarrhea at the beginning but that went away in a few days. I am more forgetful now and a little bit more irritated at times, and I've heard this could be related to Metformin.
- falcolas 2y ago
  1k pills here, but I can only take one once a day. They're really hard on the stomach, and even when taken with food. A second pill (which my doctor would like to see) just always makes me puke.
  - giardini 2y ago
    "on the stomach"? More like "the asshole! They're not called "Metfartmin" for nothing! If you want to live a long smelly life with no friends and certainly with no bed partner then Metformin may be the pill for you. I told a friend about this drug's life-extension possibilities. We set out to meet at Starbucks but, prior to leaving, he took 2 x 500-mg Metformin (he's a diabetic and so has a prescription). An hour later he arrived and confessed that his tardiness was incurred when a fart was revealed to contain a lump. He had to return home to change his pants.
robwwilliams 2y ago
TAME has not yet been funded by NIA. Stay tuned.
aanet 2y ago
Here's more info [1] on the TAM trial, courtesy of Dr Michael Greger. Apparently, the TAME trial has gotten FDA approval since 2015, but has yet to be launched as a full fledged clinical trial, apparently because "there is no way in hell to make money on it. So how would we fund a clinical trial? Well, yes, the only way is philanthropic" [2] [1] https://nutritionfacts.org/video/the-tame-trial-targeting-aging-with-metformin/ https://nutritionfacts.org/video/the-tame-trial-targeting-ag... [2] https://youtu.be/_9I0R8I16XQ?feature=shared&t=105 https://youtu.be/_9I0R8I16XQ?feature=shared&t=105

matthewdgreen 2y ago

For those who can't access the article, the dosage they used was 20mg/kg per day. The pills I've seen are 500mg, so for me that works out to 3-4 pills per day. I know some people who already take doses like that for high blood sugar with no ill effects, but some also do have ill effects. Also I am not a monkey, so no idea if this would be a great idea to try. I couldn't find the exact doses TAME is using, but some writeups point out that there's no effect on glucose levels beyond about 1,600mg per day.

thehappypm 2y ago
> Also I am not a monkey [Citation Needed]
leptons 2y ago
I've been taking 2000mg of metformin every day for years, no ill effects. I guess I'm one of the lucky ones? Also, I'm a type of monkey more commonly referred to as "human".
- snailb 2y ago
  Same here, 2kmg every day split between 1 in the morning and one in the evening. I did have Diarrhea at the beginning but that went away in a few days. I am more forgetful now and a little bit more irritated at times, and I've heard this could be related to Metformin.
falcolas 2y ago
1k pills here, but I can only take one once a day. They're really hard on the stomach, and even when taken with food. A second pill (which my doctor would like to see) just always makes me puke.
- giardini 2y ago
  "on the stomach"? More like "the asshole! They're not called "Metfartmin" for nothing! If you want to live a long smelly life with no friends and certainly with no bed partner then Metformin may be the pill for you. I told a friend about this drug's life-extension possibilities. We set out to meet at Starbucks but, prior to leaving, he took 2 x 500-mg Metformin (he's a diabetic and so has a prescription). An hour later he arrived and confessed that his tardiness was incurred when a fart was revealed to contain a lump. He had to return home to change his pants.

robwwilliams 2y ago

TAME has not yet been funded by NIA. Stay tuned.

aanet 2y ago

Here's more info [1] on the TAM trial, courtesy of Dr Michael Greger. Apparently, the TAME trial has gotten FDA approval since 2015, but has yet to be launched as a full fledged clinical trial, apparently because "there is no way in hell to make money on it. So how would we fund a clinical trial? Well, yes, the only way is philanthropic" [2] [1] https://nutritionfacts.org/video/the-tame-trial-targeting-aging-with-metformin/ https://nutritionfacts.org/video/the-tame-trial-targeting-ag... [2] https://youtu.be/_9I0R8I16XQ?feature=shared&t=105 https://youtu.be/_9I0R8I16XQ?feature=shared&t=105