3 ms·

metformin can also cause gastroparesis, which is a nasty condition I wouldn't wish on anyone.

toomuchtodo 2y ago
Something to be aware of is that it can cause genital physical deformities in male offspring. > Boys were more likely to be born with genital birth defects if their fathers took the commonly prescribed diabetes drug metformin in the three months before conception, according to a new study by Stanford Medicine investigators and their collaborators in Denmark. https://med.stanford.edu/news/all-news/2022/03/birth-defects-diabetes-drug.html https://med.stanford.edu/news/all-news/2022/03/birth-defects... https://www.acpjournals.org/doi/10.7326/M21-4389 https://www.acpjournals.org/doi/10.7326/M21-4389
- antisthenes 2y ago
  It's a good idea to go on a "purge" before attempting conception, for both males and females, lasting at least 5-6 months E.g. cut out bad foods, any drugs, exercise regularly.
caseyy 2y ago
It does often cause significant gastrointestinal problems. Same as weight loss drugs. A lot of people think these drugs are free lunch but they are not.
- epasveer 2y ago
  My experience with metformin, those gastrointestinal problems occur the first 4 months of taking it. I had an experience in a Home Depot, had to briskly walk to the bathroom. Like clenching a quater between your cheeks for a 100 yards. Barely made it. Anyway, the body adjusts. After 3 or 4 months, all is good.
  - caseyy 2y ago
    Hmm, that is a very long time to suffer the side effects. The information leaflets often say to discontinue much sooner. Well, if your doctor was okay with it, then who are internet strangers to judge? If you had the usual non-tolerance GI problems (more frequent than in 1 in 10 patients), I can only admire the perseverance. It takes a lot of self-care from keeping close to a toilet to hydration.
    - lurking_swe 2y ago
      My wife had this problem when she started metformin. After 2 weeks of diarrhea she tried a different approach, she purposely skipped her medication every other day for a week. The she gradually started taking it every day. The problems went away over night. Her doctor was baffled which is…funny. I think some drugs are more easily tolerated by the body if they are gradually introduced.
  - deleted 2y ago
    [deleted]
  - giardini 2y ago
    " Like clenching a quarter between your cheeks for a 100 yards." Is this an American game? What is it called? Who checks the quarters? How?

Something to be aware of is that it can cause genital physical deformities in male offspring. > Boys were more likely to be born with genital birth defects if their fathers took the commonly prescribed diabetes drug metformin in the three months before conception, according to a new study by Stanford Medicine investigators and their collaborators in Denmark. https://med.stanford.edu/news/all-news/2022/03/birth-defects-diabetes-drug.html https://med.stanford.edu/news/all-news/2022/03/birth-defects... https://www.acpjournals.org/doi/10.7326/M21-4389 https://www.acpjournals.org/doi/10.7326/M21-4389

antisthenes 2y ago
It's a good idea to go on a "purge" before attempting conception, for both males and females, lasting at least 5-6 months E.g. cut out bad foods, any drugs, exercise regularly.

caseyy 2y ago

It does often cause significant gastrointestinal problems. Same as weight loss drugs. A lot of people think these drugs are free lunch but they are not.

epasveer 2y ago
My experience with metformin, those gastrointestinal problems occur the first 4 months of taking it. I had an experience in a Home Depot, had to briskly walk to the bathroom. Like clenching a quater between your cheeks for a 100 yards. Barely made it. Anyway, the body adjusts. After 3 or 4 months, all is good.
- caseyy 2y ago
  Hmm, that is a very long time to suffer the side effects. The information leaflets often say to discontinue much sooner. Well, if your doctor was okay with it, then who are internet strangers to judge? If you had the usual non-tolerance GI problems (more frequent than in 1 in 10 patients), I can only admire the perseverance. It takes a lot of self-care from keeping close to a toilet to hydration.
  - lurking_swe 2y ago
    My wife had this problem when she started metformin. After 2 weeks of diarrhea she tried a different approach, she purposely skipped her medication every other day for a week. The she gradually started taking it every day. The problems went away over night. Her doctor was baffled which is…funny. I think some drugs are more easily tolerated by the body if they are gradually introduced.
- deleted 2y ago
  [deleted]
- giardini 2y ago
  " Like clenching a quarter between your cheeks for a 100 yards." Is this an American game? What is it called? Who checks the quarters? How?