Anecdotally I've experienced several PC's that became slow/unstable/unusable after a number of years. I can't scientifically prove it was due to the registry (

Anecdotally I've experienced several PC's that became slow/unstable/unusable after a number of years. I can't scientifically prove it was due to the registry (other than a couple that had specific corruption). But after I started using Total Uninstall religiously, from day 1 of a PC's life, my desktops have lasted indefinitely - going on 15 years for the latest one (yes, really). Hardware was of course upgraded along the way, making old driver removal paramount (which TU is very helpful with). Analyzing it's logs after a software installation has also been helpful to spot and surgically remove unwanted keys like autostarts, Explorer addins, etc.