The literature is overwhelming that a certain level of caloric reduction is a health master key, the body does so many things to clean up and improve and length

The literature is overwhelming that a certain level of caloric reduction is a health master key, the body does so many things to clean up and improve and lengthen lifespan and healthspan under just enough caloric reduction, people would probably routinely live to 150 in this regime. They might not be high productivity years, tho, caloric reduction implies energy conservation and guess what uses a lot of energy. Within a given caloric regime, different people's bodies and microbiota react to the same foods in different ways. They also react in different ways at different times of day/year in response to different demands and stresses. But a regime that provides needed at the time chemical components with sufficient surplus for growth is not going to activate the markers that lead to longer life, but it will lead to a much more productive life.