4 ms·
It doesnt show direction of causality. Dopamine is also an important gut neurotransmitter.
by cpncrunch 2y ago
It doesnt show direction of causality. Dopamine is also an important gut neurotransmitter.
- yieldcrv 2y agoand neither will the proposed treatments, and neither will the clinical trials, and neither will the approved drugs
- cpncrunch 2y agoMy point is that its plausible there is no direction. It could be dopamine causing both effects.
- FollowingTheDao 2y agoI agree. They know dopamine makes things worse for PD pateints. My Theory: The reason that Dopamine fails is because they do not have low dopamine, but low energy for the dopamine receptor. The dopamine receptors are G Coupled Protein receptors that need GTP to function. So if you are low in the purine GTP then it does not matter how much dopamine you make. Giving these patients dopamine works, but then fails, because it depletes the cells of GTP.
- jxntb73 2y agospeculative.
- FollowingTheDao 2y agoMy work is not based on conjecture, it’s based on knowledge. So it’s not speculative, it’s a hypothesis. This is how science works.
- jxntb73 2y agoSure. Interesting hypothesis. More research needed. *edit, for the record, for me, as a postdoc, a hypothesis, while more structured than mere speculation, is still an unproven explanation that requires rigorous testing and peer review before it can be considered established scientific knowledge, and thus remains speculative.
- FollowingTheDao 2y ago“More research needed.” You’re a postdoc and you don’t think this is obvious? That’s what follows a hypothesis in the scientific process. Make an observation or ask a question. Gather background information. Create a hypothesis. (You are here) Create a prediction and perform a test. Analyze the results and draw a conclusion. Share the conclusion or decide what question to ask next: Document the results of your experiment.