4 ms·

> At the moment, transparency is limited to the depth the dye penetrates, but Hong said microneedle patches or injections could deliver the dye more deeply. Re

by ardrak 2y ago

> At the moment, transparency is limited to the depth the dye penetrates, but Hong said microneedle patches or injections could deliver the dye more deeply. Reverse tattoos incoming.

RobotToaster 2y ago
If it dissolves in DMSO, penetration should be vastly improved.
- trhway 2y ago
  It is stated to be slightly solvable in DMSO, so that may be already enough. Anyway, i've got the impression - layman from reading some related articles - with DMSO the solubility isn't that important in the sense that DMSO seems to be temporarily increasing physical permeativity of the tissues - kind of creates micropores - so that even some not very soluble stuff can probably get through. I have a small bottle of DMSO at home, wonder if should buy some Doritos on the way home :)
- beeflet 2y ago
  What kind of application are you suggesting with DMSO? t. chem student
  - kragen 2y ago
    probably mixing dmso with tartrazine and rubbing it on thin skin. dmso is commonly used as an excipient to promote dermal penetration (of the stratum corneum) by drugs in topical preparations see https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3460663/ https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3460663/
FjordWarden 2y ago
Sorry for being nerd, but your internal organs are going to get UV damage.
- deleted 2y ago
  [deleted]
- murphyslab 2y ago
  UV damage to internal tissues seems unlikely given that the tartrazine dye they used absorbs strongly in the UV region of the spectrum. You can see this in Figure S1 A & B: https://www.science.org/doi/suppl/10.1126/science.adm6869/suppl_file/science.adm6869_sm.pdf https://www.science.org/doi/suppl/10.1126/science.adm6869/su... Also the abstract of the article notes that strong UV absorption is likely a prerequisite for this effect: > We hypothesized that strongly absorbing molecules can achieve optical transparency in live biological tissues. By applying the Lorentz oscillator model for the dielectric properties of tissue components and absorbing molecules, we predicted that dye molecules with sharp absorption resonances in the near-ultraviolet spectrum (300 to 400 nm) and blue region of the visible spectrum (400 to 500 nm) are effective in raising the real part of the refractive index of the aqueous medium at longer wavelengths when dissolved in water, which is in agreement with the Kramers-Kronig relations. As a result, water-soluble dyes can effectively reduce the RI contrast between water and lipids, leading to optical transparency of live biological tissues. https://www.science.org/doi/10.1126/science.adm6869 https://www.science.org/doi/10.1126/science.adm6869 However this kind of research into the effects of absorption bands on the transmission properties at interfaces might ultimately bring about more effective sunscreen formulations.
  - JumpCrisscross 2y ago
    > UV damage to internal tissues seems unlikely given that the tartrazine dye they used absorbs strongly in the UV region of the spectrum To expand: "the most hazardous UV radiation has wavelengths between 240 nm and 300 nm" [2]. While tartrazine has a lambda max at 425 nm in water [2], it has a second ridiculously-convenient peak around 260 nm [3]. TL; DR It should be mildly UV protective ceteris paribus. [1] https://ehs.umass.edu/sites/default/files/UV%20Fact%20Sheet.pdf https://ehs.umass.edu/sites/default/files/UV%20Fact%20Sheet.... [2] https://pubchem.ncbi.nlm.nih.gov/compound/Tartrazine#section=UV-Spectra&fullscreen=true https://pubchem.ncbi.nlm.nih.gov/compound/Tartrazine#section... [3] https://www.aatbio.com/absorbance-uv-visible-spectrum-graph-viewer/tartrazine_acid_yellow_23 https://www.aatbio.com/absorbance-uv-visible-spectrum-graph-...
HPsquared 2y ago
"Alpha channel" dye.
BobbyJo 2y ago
Your immune system traps and isolates tattoo ink and prevents it from free contact with other tissues, so I don't see that working in practice.

by ardrak 2y ago

> At the moment, transparency is limited to the depth the dye penetrates, but Hong said microneedle patches or injections could deliver the dye more deeply. Reverse tattoos incoming.

RobotToaster 2y ago

If it dissolves in DMSO, penetration should be vastly improved.

trhway 2y ago
It is stated to be slightly solvable in DMSO, so that may be already enough. Anyway, i've got the impression - layman from reading some related articles - with DMSO the solubility isn't that important in the sense that DMSO seems to be temporarily increasing physical permeativity of the tissues - kind of creates micropores - so that even some not very soluble stuff can probably get through. I have a small bottle of DMSO at home, wonder if should buy some Doritos on the way home :)
beeflet 2y ago
What kind of application are you suggesting with DMSO? t. chem student
- kragen 2y ago
  probably mixing dmso with tartrazine and rubbing it on thin skin. dmso is commonly used as an excipient to promote dermal penetration (of the stratum corneum) by drugs in topical preparations see https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3460663/ https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3460663/

FjordWarden 2y ago

Sorry for being nerd, but your internal organs are going to get UV damage.

deleted 2y ago
[deleted]
murphyslab 2y ago
UV damage to internal tissues seems unlikely given that the tartrazine dye they used absorbs strongly in the UV region of the spectrum. You can see this in Figure S1 A & B: https://www.science.org/doi/suppl/10.1126/science.adm6869/suppl_file/science.adm6869_sm.pdf https://www.science.org/doi/suppl/10.1126/science.adm6869/su... Also the abstract of the article notes that strong UV absorption is likely a prerequisite for this effect: > We hypothesized that strongly absorbing molecules can achieve optical transparency in live biological tissues. By applying the Lorentz oscillator model for the dielectric properties of tissue components and absorbing molecules, we predicted that dye molecules with sharp absorption resonances in the near-ultraviolet spectrum (300 to 400 nm) and blue region of the visible spectrum (400 to 500 nm) are effective in raising the real part of the refractive index of the aqueous medium at longer wavelengths when dissolved in water, which is in agreement with the Kramers-Kronig relations. As a result, water-soluble dyes can effectively reduce the RI contrast between water and lipids, leading to optical transparency of live biological tissues. https://www.science.org/doi/10.1126/science.adm6869 https://www.science.org/doi/10.1126/science.adm6869 However this kind of research into the effects of absorption bands on the transmission properties at interfaces might ultimately bring about more effective sunscreen formulations.
- JumpCrisscross 2y ago
  > UV damage to internal tissues seems unlikely given that the tartrazine dye they used absorbs strongly in the UV region of the spectrum To expand: "the most hazardous UV radiation has wavelengths between 240 nm and 300 nm" [2]. While tartrazine has a lambda max at 425 nm in water [2], it has a second ridiculously-convenient peak around 260 nm [3]. TL; DR It should be mildly UV protective ceteris paribus. [1] https://ehs.umass.edu/sites/default/files/UV%20Fact%20Sheet.pdf https://ehs.umass.edu/sites/default/files/UV%20Fact%20Sheet.... [2] https://pubchem.ncbi.nlm.nih.gov/compound/Tartrazine#section=UV-Spectra&fullscreen=true https://pubchem.ncbi.nlm.nih.gov/compound/Tartrazine#section... [3] https://www.aatbio.com/absorbance-uv-visible-spectrum-graph-viewer/tartrazine_acid_yellow_23 https://www.aatbio.com/absorbance-uv-visible-spectrum-graph-...

HPsquared 2y ago

"Alpha channel" dye.

BobbyJo 2y ago

Your immune system traps and isolates tattoo ink and prevents it from free contact with other tissues, so I don't see that working in practice.