I've had nix disappear out from under me a couple times on Mac, enough for me to start drifting away from home manager. Sucks cuz I like the tooling! But serio

I've had nix disappear out from under me a couple times on Mac, enough for me to start drifting away from home manager. Sucks cuz I like the tooling! But seriously, let's say you have a Python project (like a Django application with a couple requirements in your `requirements.txt`), what is the least disruptive way to get it working? Many things I've looked at involved doing one-time transformations of requirements files or otherwise easy-to-desync things...