4 ms·
> The studies - part of the Select trial - tracked more than 17,600 people, aged 45 or older, as they were given either 2.4 mg of semaglutide or a placebo for m
by Mistletoe 2y ago
> The studies - part of the Select trial - tracked more than 17,600 people, aged 45 or older, as they were given either 2.4 mg of semaglutide or a placebo for more than three years. Participants were obese or overweight and had cardiovascular disease but not diabetes.
Exciting stuff. What does data look like in people that aren’t obese?
- smt88 2y agoCalorie restriction is a well-studied (though not terribly healthy) way to slow aging. It's likely these drugs are just making it easier for people.
- kiba 2y agoCalories restriction worked in a wide variety of species but was inconclusive in monkeys and was never proven in humans.
- smt88 2y agoI'm not sure what standard you're using for "proven," but there are a lot of studies showing results similar to this one: https://www.publichealth.columbia.edu/news/calorie-restriction-slows-pace-aging-healthy-adults https://www.publichealth.columbia.edu/news/calorie-restricti... There don't seem to be any huge, long-term studies, but here is a review of what's available as of a few years ago: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7468870/ https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7468870/
- woleium 2y agoSee Roy Walford et al out of UCLA on the CRON diet. Its not a nice way to live, but it seems to be safe and healthy.
- smt88 2y agoI'll have to look into it more, but from what I've seen, it seemed that people had to restrict calories so much that their immune system was underactive (which may be a large part of why it works).
- woleium 2y agoInteresting, i last looked at this over 10 years ago, i assume this came to light more recently than that.
- rendaw 2y agoI thought calorie restriction was another order of magnitude, beyond "normal" weight. But I guess if obesity was causing accelerated ageing, you could say not being obese is delaying ageing.
- smt88 2y agoIt varies from study to study, but generally what I've seen for anti-aging is ~1,000 calories per day or less. I've seen it as low as 500.
- 7speter 2y agoWill the non-obese people be subject to gastroparesis and all that entails?
- wmf 2y agoI don't think this should be downvoted. For overweight people, the benefits of these drugs exceed the risks of side effects, but for healthy people there may be no benefits.
- hooo 2y agoThis is a good question- I’m not sure why you’re down voted.