6 ms·
Ozempic could delay ageing, researchers suggest
- Mistletoe 2y ago> The studies - part of the Select trial - tracked more than 17,600 people, aged 45 or older, as they were given either 2.4 mg of semaglutide or a placebo for more than three years. Participants were obese or overweight and had cardiovascular disease but not diabetes. Exciting stuff. What does data look like in people that aren’t obese?
- smt88 2y agoCalorie restriction is a well-studied (though not terribly healthy) way to slow aging. It's likely these drugs are just making it easier for people.
- kiba 2y agoCalories restriction worked in a wide variety of species but was inconclusive in monkeys and was never proven in humans.
- smt88 2y agoI'm not sure what standard you're using for "proven," but there are a lot of studies showing results similar to this one: https://www.publichealth.columbia.edu/news/calorie-restriction-slows-pace-aging-healthy-adults https://www.publichealth.columbia.edu/news/calorie-restricti... There don't seem to be any huge, long-term studies, but here is a review of what's available as of a few years ago: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7468870/ https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7468870/
- woleium 2y agoSee Roy Walford et al out of UCLA on the CRON diet. Its not a nice way to live, but it seems to be safe and healthy.
- smt88 2y agoI'll have to look into it more, but from what I've seen, it seemed that people had to restrict calories so much that their immune system was underactive (which may be a large part of why it works).
- woleium 2y agoInteresting, i last looked at this over 10 years ago, i assume this came to light more recently than that.
- rendaw 2y agoI thought calorie restriction was another order of magnitude, beyond "normal" weight. But I guess if obesity was causing accelerated ageing, you could say not being obese is delaying ageing.
- smt88 2y agoIt varies from study to study, but generally what I've seen for anti-aging is ~1,000 calories per day or less. I've seen it as low as 500.
- 7speter 2y agoWill the non-obese people be subject to gastroparesis and all that entails?
- wmf 2y agoI don't think this should be downvoted. For overweight people, the benefits of these drugs exceed the risks of side effects, but for healthy people there may be no benefits.
- hooo 2y agoThis is a good question- I’m not sure why you’re down voted.
- heraldgeezer 2y agoIs this due to the drug itself or due to eating less? Another tip is to stay out of the sun.
- nikkwong 2y ago*Another tip is to stay in the sun. The data on sun exposure has largely reversed over the last decade; sun exposure is positively correlated with improved health outcomes, but should be done in moderation as to prevent skin issues.
- AlexandrB 2y agoWhere "moderation" means something like 15-30 minutes[1]. [1] https://www.webmd.com/a-to-z-guides/ss/slideshow-sunlight-health-effects https://www.webmd.com/a-to-z-guides/ss/slideshow-sunlight-he...
- yjftsjthsd-h 2y agoThat link says > In general, scientists think 5 to 15 minutes -- up to 30 if you’re dark-skinned -- is about right to get the most out of it without causing any health problems.
- heraldgeezer 2y agoYes. And people tan waaaaaaaaaaay more or work outside.
- dirtdobber 2y agoIt turns out that food is also healthy for you, in moderation. Alas, we need a drug to help us moderate.
- fnord77 2y agoyes, because historically, food has been so scarce that we never evolved a shutoff mechanism on our own.
- paulpauper 2y agoreducing weight is positively correlated with improved health outcomes in every respect
- pokstad 2y agoDoesn’t Ozempic have a bunch of serious side effects besides weight loss?
- rapsey 2y agoSide effect is also losing muscle mass
- r00fus 2y agoPeople who are overweight have much more muscle mass than people who normal weight. Losing that muscle mass is normal
- declan_roberts 2y agoFat guys can do incredible leg press and calf raise numbers.
- declan_roberts 2y agoNot only do you live longer, but you live better!
- boguscoder 2y agoIm not questioning the quoted studies in any way but its either my language barrier or BBC has built a clickbaity title based on just one quote “ It wouldn't surprise me that improving people's health this way actually slows down the ageing process” Wonder what would they write had he said “it wouldn’t surprise me if people get blue skin and tiny horns…”
- amriksohata 2y agobbc lol
- fnord77 2y agoit's been shown that metformin reduced all-cause mortality, so this isn't surprising.
- SebFender 2y agoThese articles are really dangerous and similar research stating such global implications when many starting points are... "Participants were obese or overweight and had cardiovascular disease but not diabetes." Stay fit and be active.