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The smarter way to look at it: Diabetes increases the chances of dementia. It's diabetes that's causing an unnatural increase. Rhe drug is simply a catalyst for

The smarter way to look at it: Diabetes increases the chances of dementia. It's diabetes that's causing an unnatural increase. Rhe drug is simply a catalyst for something closer to normal. Obesity at it's current rate, while socially normalized, is from an evolutionary standpoint abnormal.

vessenes 2y ago
The article mentions that this effect was seen in only the cohort taking one of two prevalent diabetes medications. For your interpretation to be accurate, you’d need to also show that the other popular medicine doesn’t work for diabetes type 2 treatment. FWIW, the last line of the article is a dismissal from a UK doctor saying that this would make the diabetes drug better than any existing Alzheimer treatments, and suggesting that there’s a confounding variable in the study instead.
- yieldcrv 2y ago
  or the Alzheimer’s treatments aren’t treating sugar buildup as amyloid plaques, and instead are trying to manage Alzheimer symptoms But I don't know though
  - rob_c 2y ago
    I thought there had been enough discussion recently about how the plaque isn't the trigger of but probably just another effect?
    - yieldcrv 2y ago
      I had read that too, but while those Alzheimer’s teams pivot over the next 10 years for their new research and drug approvals, the thing that treats insulin and glucose processing helps prevent diabetes and dementia
- giantg2 2y ago
  "For your interpretation to be accurate, you’d need to also show that the other popular medicine doesn’t work for diabetes type 2 treatment." This is not true. It's possible that there are multiple effects of type 2 diabetes, with multiple drugs that treat the main factor (sugar levels), but with a subset of the drugs affecting other factors (hormones, cellular activities, something else) that influence dementia.
madmads 2y ago
The smarter way to comment online: Read the article before commenting on how to best understand it. As the other reader mentioned, that's not what the article says.
- chiefalchemist 2y ago
  So be complicit in the article's false paradigm? That is, the medication doesn't improve anything per se. The problem is obesity and diabetes. The medication does not perform better than these not being present at all. The presume diabetes - sans T1 - is a norm is false if not dangerous. In other words, "Sure just throw more meds at it" is not a narrative anyone should be comfortable with.
nabla9 2y ago
Look up "confounding variable" and think again https://en.wikipedia.org/wiki/Confounding https://en.wikipedia.org/wiki/Confounding What you describe is not smarter way. It's jumping to conclusions.
- chiefalchemist 2y ago
  No actually, I'm not. Instead, my baseline is the historic norm, the evolutionary norm. I don't jump to the conclusion of normalizing diabetes and then come up with some throw-more-pills-at-it theory. In other words, how effective is this "cure" vs no diabetes at all? *That* is the question.
InDubioProRubio 2y ago
From an evolutionary standpoint, animals cycle from obese to slim year round. Obesity is normal in autumn. Being slim is normal in spring/early summer. Food state wise we are in a eternal autumn.
- chmod775 2y ago
  There's no "normal" obesity or time when obesity is normal. The disease is characterized by an abnormal weight by definition. An animal who has a normal weight for one of its species at some time of year is not obese.
  - lostapathy 2y ago
    Bears that go into winter slim aren’t bears at all come spring.
    - lm28469 2y ago
      Yeah because bears totally have the same lifestyle and hibernation patterns has humans...
      - CRConrad 2y ago
        Of course we don't, but then again I think bears were just thrown in as an (extreme) example. As I read the thread before that, the point was that most animals' weights vary on an annual cycle, fattened up during summer-autumn and slimmer after the winter. Which seems fairly uncontroversial to me.
    - bequanna 2y ago
      Humans are not bears. Also, the life expectancy of humans is >10x a bear. Why are people bending over backwards to normalize diabetes and obesity? The weeds in a garden need to be pulled or they will take the garden. Problems need to be recognized and then fixed, anything else is delusion.

vessenes 2y ago

The article mentions that this effect was seen in only the cohort taking one of two prevalent diabetes medications. For your interpretation to be accurate, you’d need to also show that the other popular medicine doesn’t work for diabetes type 2 treatment. FWIW, the last line of the article is a dismissal from a UK doctor saying that this would make the diabetes drug better than any existing Alzheimer treatments, and suggesting that there’s a confounding variable in the study instead.

yieldcrv 2y ago
or the Alzheimer’s treatments aren’t treating sugar buildup as amyloid plaques, and instead are trying to manage Alzheimer symptoms But I don't know though
- rob_c 2y ago
  I thought there had been enough discussion recently about how the plaque isn't the trigger of but probably just another effect?
  - yieldcrv 2y ago
    I had read that too, but while those Alzheimer’s teams pivot over the next 10 years for their new research and drug approvals, the thing that treats insulin and glucose processing helps prevent diabetes and dementia
giantg2 2y ago
"For your interpretation to be accurate, you’d need to also show that the other popular medicine doesn’t work for diabetes type 2 treatment." This is not true. It's possible that there are multiple effects of type 2 diabetes, with multiple drugs that treat the main factor (sugar levels), but with a subset of the drugs affecting other factors (hormones, cellular activities, something else) that influence dementia.

madmads 2y ago

The smarter way to comment online: Read the article before commenting on how to best understand it. As the other reader mentioned, that's not what the article says.

chiefalchemist 2y ago
So be complicit in the article's false paradigm? That is, the medication doesn't improve anything per se. The problem is obesity and diabetes. The medication does not perform better than these not being present at all. The presume diabetes - sans T1 - is a norm is false if not dangerous. In other words, "Sure just throw more meds at it" is not a narrative anyone should be comfortable with.

nabla9 2y ago

Look up "confounding variable" and think again https://en.wikipedia.org/wiki/Confounding https://en.wikipedia.org/wiki/Confounding What you describe is not smarter way. It's jumping to conclusions.

chiefalchemist 2y ago
No actually, I'm not. Instead, my baseline is the historic norm, the evolutionary norm. I don't jump to the conclusion of normalizing diabetes and then come up with some throw-more-pills-at-it theory. In other words, how effective is this "cure" vs no diabetes at all? *That* is the question.

InDubioProRubio 2y ago

From an evolutionary standpoint, animals cycle from obese to slim year round. Obesity is normal in autumn. Being slim is normal in spring/early summer. Food state wise we are in a eternal autumn.

chmod775 2y ago
There's no "normal" obesity or time when obesity is normal. The disease is characterized by an abnormal weight by definition. An animal who has a normal weight for one of its species at some time of year is not obese.
- lostapathy 2y ago
  Bears that go into winter slim aren’t bears at all come spring.
  - lm28469 2y ago
    Yeah because bears totally have the same lifestyle and hibernation patterns has humans...
    - CRConrad 2y ago
      Of course we don't, but then again I think bears were just thrown in as an (extreme) example. As I read the thread before that, the point was that most animals' weights vary on an annual cycle, fattened up during summer-autumn and slimmer after the winter. Which seems fairly uncontroversial to me.
  - bequanna 2y ago
    Humans are not bears. Also, the life expectancy of humans is >10x a bear. Why are people bending over backwards to normalize diabetes and obesity? The weeds in a garden need to be pulled or they will take the garden. Problems need to be recognized and then fixed, anything else is delusion.