3 ms·

Very cool! Are there other vaccines that have been formulated for mucosal ingestion? What makes that delivery method so effective?

ZoomerCretin 2y ago
There's a nasal flu vaccine as well. Theoretically, it's supposed to induce immunity in mucous membranes and prevent infections in the first place, rather than merely reducing symptom severity. As for how effective it actually is at those goals, we'll have to see.
- pixiemaster 2y ago
  nasal flu is heavily used in scotlands schools, wheee flu vaccination is mandatory.
roenxi 2y ago
> What makes that delivery method so effective? This seems like an easy one to guess - your immune system has been developed over a very long time, is highly complex and has layers of defences everywhere that are all a little different. Training it to look for coronavirus in your muscles is less effective against coronaviruses than training it to look for infections in nasal mucus where said virus is actually trying to enter and exit the body.
bbzealot 2y ago
There were other similar (ie. nasal) vaccine candidates for COVID, like the Cuban MAMBISA [0], though it seems it never got final approval
duskwuff 2y ago
Some canine vaccines against respiratory infections are given as a nasal spray, e.g. https://www.merck-animal-health-usa.com/nobivac/nobivac-intra-trac3 https://www.merck-animal-health-usa.com/nobivac/nobivac-intr...
Amezarak 2y ago
Your immune system has different "compartments." The mucosal immune compartment produces its own antibodies and its own immune response. The "jab" did not immunize the mucosal immune compartment, so people could and did catch and spread Covid - but they were protected from developing a serious infection because the virus was unable to spread in their body further. As it invades through your respiratory system, vaccinating the mucosal immune compartment means its stopped at the point of entry and does not spread to others or develop into even a mild case.

ZoomerCretin 2y ago

There's a nasal flu vaccine as well. Theoretically, it's supposed to induce immunity in mucous membranes and prevent infections in the first place, rather than merely reducing symptom severity. As for how effective it actually is at those goals, we'll have to see.

pixiemaster 2y ago
nasal flu is heavily used in scotlands schools, wheee flu vaccination is mandatory.

roenxi 2y ago

> What makes that delivery method so effective? This seems like an easy one to guess - your immune system has been developed over a very long time, is highly complex and has layers of defences everywhere that are all a little different. Training it to look for coronavirus in your muscles is less effective against coronaviruses than training it to look for infections in nasal mucus where said virus is actually trying to enter and exit the body.

bbzealot 2y ago

There were other similar (ie. nasal) vaccine candidates for COVID, like the Cuban MAMBISA [0], though it seems it never got final approval

duskwuff 2y ago

Some canine vaccines against respiratory infections are given as a nasal spray, e.g. https://www.merck-animal-health-usa.com/nobivac/nobivac-intra-trac3 https://www.merck-animal-health-usa.com/nobivac/nobivac-intr...

Amezarak 2y ago

Your immune system has different "compartments." The mucosal immune compartment produces its own antibodies and its own immune response. The "jab" did not immunize the mucosal immune compartment, so people could and did catch and spread Covid - but they were protected from developing a serious infection because the virus was unable to spread in their body further. As it invades through your respiratory system, vaccinating the mucosal immune compartment means its stopped at the point of entry and does not spread to others or develop into even a mild case.