5 ms·

Metformin has been the 1st choice for treatment of type 2 diabetes for decades. Countless millions have taken it daily for many years. Although I’m sure some lo

by tssva 2y ago

Metformin has been the 1st choice for treatment of type 2 diabetes for decades. Countless millions have taken it daily for many years. Although I’m sure some lose weight taking the impact is not near as significant or wide spread as glp-1s. I have taken it for 20 years and never lost weight while on it. If there was significant weight loss across a large range of those taking it you would have heard a lot more about metformin being used for weight loss. I have taken Mounjaro since February and have experienced significant weight loss and my A1C has fallen to 5.3 which is significantly lower than on metformin alone or in combination with other type 2 medications.

pfdietz 2y ago
My personal experience with metformin was it didn't cause weight loss, until I deliberately also tried diet (< 100 g net carbs per day) and exercise (~4 miles walking/day). That ended up being much easier to stick to than I had previously found it to be, and has caused me to slowly but steadily lose 25 pounds since May.
- tssva 2y ago
  That reads to me that you have lost weight due to a combination of diet and exercise. Not necessarily metformin.
  - pfdietz 2y ago
    The key point was that it was very weirdly easy, compared to previous efforts, and I credit metformin (1000 mg/day) for that.