iTerm2 running tmux. That's where I run vim and irssi. As for GUI stuff. * Alfred - Alfred will make you 100 times more productive moving around your system.

iTerm2 running tmux. That's where I run vim and irssi. As for GUI stuff. * Alfred - Alfred will make you 100 times more productive moving around your system. * Spotlight - Even if you don't use Alfred, spotlight will make you more productive * AppZapper - Uninstalls apps and removes all the little things that get left behind when dragging apps to the trash. * Automator - A lot of people don't ever learn automator, but I think it's the best thing ever. It comes with OS X and it's awesome. I write little tasks all the time for example, I have an automator task that zips my project directory with a timestamp in the name and moves it to dropbox every day at 4:55pm for backup. * Billings - If you do contract work Billings is amazing * Github.app - Amazing tool * Growl - Amazing nofitications * LittleSnapper - Fantastic tool for keeping track of screenshots of designs and such * Mou - Great little markdown editor * Propane - Fantastic campfire client * Skala Preview - Allows you to connect to photoshop and see your iOS psd's realtime on your iOS device * Textmate - Amazing text editor * Transmit - Best ftp client hands down * Wakeup Time - Turns your Macbook into an alarm clock