There was always a lot of evidence to suggest that Amyloid plaque was not the cause of the problem but a sign of the activity causing the issue and the fact it

There was always a lot of evidence to suggest that Amyloid plaque was not the cause of the problem but a sign of the activity causing the issue and the fact it was the only pursued strategy for years speaks to a problem in medicine and research funding getting very railroaded at times. Many diseases have many potential causes but once a favourite gets selected there is a real tendency for all efforts to go towards that theory and even when early signs are its wrong it continues for years. Alzheimer research went seriously wrong for multiple decades.