That would be interesting. I could be wrong about the photographer, but I believe it was Eugene Atget who has a photograph of a completely empty Paris street

That would be interesting. I could be wrong about the photographer, but I believe it was Eugene Atget who has a photograph of a completely empty Paris street (I cound't find it online), one that is usually bustling. His effect was achieved by a very long time exposure, a consequence of the technology at the time. Parisians were turned off by its creepy nature, and think your idea would definitely bring an eerie feel to Times Square.