https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10141840/ https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10141840/ > Micro- and Nanoplastics Breach the Blood–Brain

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10141840/ https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10141840/ > Micro- and Nanoplastics Breach the Blood–Brain Barrier (BBB): Biomolecular Corona’s Role Revealed > The blood–brain barrier (BBB) is an important biological barrier that protects the brain from harmful substances. In our study we performed short term uptake studies in mice with orally administered polystyrene micro-/nanoparticles (9.55 µm, 1.14 µm, 0.293 µm). We show that nanometer sized particles—but not bigger particles—reach the brain within only 2 h after gavage. To understand the transport mechanism, we performed coarse-grained molecular dynamics simulations on the interaction of DOPC bilayers with a polystyrene nanoparticle in the presence and absence of various coronae. We found that the composition of the biomolecular corona surrounding the plastic particles was critical for passage through the BBB. Cholesterol molecules enhanced the uptake of these contaminants into the membrane of the BBB, whereas the protein model inhibited it.