This is why I like Github's feature to add comments before posting the full review. You can do a round of nitpick comments, take some time away to let the rest

This is why I like Github's feature to add comments before posting the full review. You can do a round of nitpick comments, take some time away to let the rest settle, come back and re-review with the big picture. You can then add those comments as well, remove some of the nitpicks if they aren't relevant/important enough anymore, etc.