6 ms·

Damn, that molecule! https://en.m.wikipedia.org/wiki/Tirzepatide#/media/File%3ATirzepatide_structure.svg https://en.m.wikipedia.org/wiki/Tirzepatide#/media/Fil

• cm2012 2y ago
  The same, both came from studying Gila Monster venom in the 90s!
  • tstrimple 2y ago
    I had no idea! Fascinating. https://www.genesislifestylemedicine.com/blog/the-science-behind-glp-1-and-the-gila-monster/ https://www.genesislifestylemedicine.com/blog/the-science-be...
• sk11001 2y ago
  Yes, semaglutide (made by Novo Nordisk, brand names Ozempic, Wegovy) is a GLP-1 agonist; tirzepatide (made by Eli Lilly, brand names Mounjaro, Zepbound) is a dual GLP-1 and GIP agonist. Tirzepatide is newer and more effective, otherwise they're very similar - once a week injection, significantly reduces appetite, the use cases are diabetes and weight loss. Eli Lilly also have retatrutide in their pipeline which is a triple (GLP-1, GIP, glucagon) agonist, and which will likely be even better and will be available in a couple of years.
• astura 2y ago
  >This seems to work very similar to Ozempic? Yes, both drugs are Glucagon-like peptide-1 (GLP-1) receptor agonists. https://en.wikipedia.org/wiki/GLP-1_receptor_agonist https://en.wikipedia.org/wiki/GLP-1_receptor_agonist
• petesergeant 2y ago
  Anecdotally (and in studies) it's much more effective, though. Retatrutide is the next gen one you could look up.