You'd most likely need to run it in a VM and either implement the needed APIs or implement whatever the official OS needs to run (RPCS3 has you download the OS

You'd most likely need to run it in a VM and either implement the needed APIs or implement whatever the official OS needs to run (RPCS3 has you download the OS from Sony and implements whatever needed to run, Xenia on the other hand -Xbox360 emulator- reimplements the OS so that you don't need anything from Microsoft).