> Conversely, the study found a positive relationship between high levels of magnesium and those of folate and vitamin B12. Magnesium is known to be involved i

> Conversely, the study found a positive relationship between high levels of magnesium and those of folate and vitamin B12. Magnesium is known to be involved in "activating" riboflavin[1] into FMN, which then is involved in "activating" folate and B12 (and B6)[2][3] by transferring the methyl group back and forth to form methylfolate and methylcobalamin. Homocysteine level is often considered a useful measurement of vitamin B12 status. [1] https://www.uniprot.org/uniprotkb/Q969G6/entry https://www.uniprot.org/uniprotkb/Q969G6/entry magnesium is also involved in ATP production, zinc is also a cofactor in this reaction [2] https://lpi.oregonstate.edu/book/export/html/99#:~:text=Riboflavin%20(as%20FAD%20or%20FMN)%20is%20required%20for%20the%20synthesis,a%20key%20folate%2Dmetabolizing%20enzyme https://lpi.oregonstate.edu/book/export/html/99#:~:text=Ribo.... [3] https://lpi.oregonstate.edu/mic/vitamins/riboflavin https://lpi.oregonstate.edu/mic/vitamins/riboflavin