OrbStack (proprietary WSL and Docker Desktop clone for macOS with a GUI management application, very well made) uses LXC for all its 'Machine' guests, including

OrbStack (proprietary WSL and Docker Desktop clone for macOS with a GUI management application, very well made) uses LXC for all its 'Machine' guests, including NixOS. Consequently, I can say that I use NixOS under LXC on aarch64 almost every day at work. :) It runs perfectly well under LXC! NixOS also works well under WSL2 on Windows, though setting that up takes more footwork. If you're thinking about playing around with NixOS, virtualizing it— whether hardware or OS virtualization, whether on your laptop/desktop or in your homelab— is a great way to go.