6 ms·

Okay, so this miracle drug isn't a miracle either. Which miracle drug is?!?! I'm not asking sarcastically or ironically- I'm sincerely begging for miracles.

Okay, so this miracle drug isn't a miracle either. Which miracle drug is?!?! I'm not asking sarcastically or ironically- I'm sincerely begging for miracles. Anyone??

klipt 2y ago
Exercise often and eat healthy. "You rush a miracle man, you get rotten miracles."
- isoprophlex 2y ago
  And don't stress too much, either
brg 2y ago
Aspirin, Caffeine for two.
refurb 2y ago
Plenty of them, but they tend to be FDA approved. Take the treatments for spinal muscular atrophy. If you’re born with the worst type, you die before age 2 from respiratory failure. Today? Start treatment at birth and you live a normal life.
jaggederest 2y ago
Penicillin, polio vaccine, thorazine, morphine, cisplatin, phenol, arguably semaglutide is the most recent. There have been miracle drugs released every decade or so since the early 1900s. They're just normal now. They stop being a miracle once we're used to them. People used to die of fevers. Of sepsis. And there was nothing that could be done. Let alone cancer.
- jaggederest 2y ago
  Oh I forgot about insulin. A little over 1% of the people currently alive would be rapidly dead without it.
  - deleted 2y ago
    [deleted]
nwienert 2y ago
GLP-1 agonists. https://www.astralcodexten.com/p/why-does-ozempic-cure-all-diseases?publication_id=89120&post_id=147025858&isFreemail=true&r=3l29m&triedRedirect=true https://www.astralcodexten.com/p/why-does-ozempic-cure-all-d... Beyond their somewhat miraculous effects on obesity, they seem to have a wide variety of positive effects even for non-overweight people. They are likely the best and broadest thing we have for stopping negative addictions. They have incredibly positive effects for immune issues. Plus strong early trial results for Parkinson's, Alzheimers, and heart and kidney disease. I also think they are underrated and there may be some alpha in them for a few reasons: 1. People seem to hate the idea that someone can "cheat" at losing weight, almost seeming to hope they have some unknown side effect. 2. People seem to dismiss them as "only working because obesity causes all those issues", probably the biggest fallacy as we have evidence already, and I think will find much more, that the addictive, immune, kidney and heart effects are not due to weight loss/fasting. 3. People don't seem to realize how huge a deal it is if they do have a strong effect on immune issues - immune system issues underly so many health issues of different names from allergies to Alzheimers to all sorts of terrible diseases, and I now know a couple non-overweight people who have reported nearly miraculous results with them. 4. Their effects on addiction likewise just by themselves are big. Another friend/smoker since high school, smokes nearly a pack a day tried it and for the first time since HS didn't smoke a cigarette for a whole day - multiple days in a row. BTW it seems tirzepatide is significantly better for at least some of these effects than semaglutide.
- user_7832 2y ago
  What's slightly interesting to me is that some effects of adhd medications (particularly methylphenidate) sound quite similar - it too (can) change motivation regarding food (and actually can make unhealthy donuts seem disgusting) and of course suppresses apptetite (sometimes a little too much). I'd love to know if anyone who's taken both mph & a GLP-1 agonist how similar/different they are. (There's other interesting aspects of mph too - like how it can change sensitivities - and actually make light mode not feel like your eyes are on fire! - but that's a comment probably for another time.)
  - nwienert 2y ago
9dev 2y ago
Not the answer you’re looking for, but mRNA vaccines as used for COVID are nothing short of a miracle. The bioengineering behind them, the logistics of it all—it was incredible.
- kev009 2y ago
  Maybe if it did what they said it would instead of moving the goal posts around to fit what actually happened.
- chriscappuccio 2y ago
  An incredible waste you mean?
thomasfedb 2y ago
Paracetamol (acetaminophen) - a fairly effective, synergistic, non-addictive, predictably dosed, analgesic.
- akoboldfrying 2y ago
  Which, TTBOMK, we still don't understand the mechanism of at all. But yes, it's fantastic stuff!
  - car 2y ago
    ttbomk?
    - akoboldfrying 2y ago
      To the best of my knowledge
- The_Colonel 2y ago
  It's not addictive, but you gain tolerance. IIRC it's also hard on liver, esp. in combination with alcohol (which js unfortunate since it's otherwise good for hangover).
  - car 2y ago
    Correct, makes for a nasty death. ~8 grams and your liver is toast. https://en.wikipedia.org/wiki/Paracetamol_poisoning https://en.wikipedia.org/wiki/Paracetamol_poisoning
  - arcticbull 2y ago
    Leading cause of acute liver failure in the US, because the active dose is far closer to the lethal dose than many other OTC drugs. Not clear to me it would actually be approved if it were submitted today. It is particularly neat because it's not just a pain suppressant, it's a general emotion suppressant. > ... [it] blunts physical and social pain by reducing activation in brain areas (i.e. anterior insula and anterior cingulate) thought to be related to emotional awareness and motivation. [1] It also reduces the empathy for pain. [2] [1] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6455058/ https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6455058/ [2] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5015806/ https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5015806/
arcticbull 2y ago
Rapamycin, maybe metformin - both for life extension and to reduce the incidence of cancer and CVD.
oezi 2y ago
Your question should be split into two parts: - Miracle drugs for curing ailments. We have plenty of those. - Miracle drugs for enhancing beyond normal. Many things which work also have serious side-effects. Most things which are peddled with prescription don't have any effect.
pshirshov 2y ago
Thymopoetin analogues (or bovine one but there are more associated risks).A single injection makes you feel tens of years younger for a short time and wipes chronic infections.

Okay, so this miracle drug isn't a miracle either. Which miracle drug is?!?! I'm not asking sarcastically or ironically- I'm sincerely begging for miracles. Anyone??

klipt 2y ago

Exercise often and eat healthy. "You rush a miracle man, you get rotten miracles."

isoprophlex 2y ago
And don't stress too much, either

brg 2y ago

Aspirin, Caffeine for two.

refurb 2y ago

Plenty of them, but they tend to be FDA approved. Take the treatments for spinal muscular atrophy. If you’re born with the worst type, you die before age 2 from respiratory failure. Today? Start treatment at birth and you live a normal life.

jaggederest 2y ago

Penicillin, polio vaccine, thorazine, morphine, cisplatin, phenol, arguably semaglutide is the most recent. There have been miracle drugs released every decade or so since the early 1900s. They're just normal now. They stop being a miracle once we're used to them. People used to die of fevers. Of sepsis. And there was nothing that could be done. Let alone cancer.

jaggederest 2y ago
Oh I forgot about insulin. A little over 1% of the people currently alive would be rapidly dead without it.
- deleted 2y ago
  [deleted]

nwienert 2y ago

GLP-1 agonists. https://www.astralcodexten.com/p/why-does-ozempic-cure-all-diseases?publication_id=89120&post_id=147025858&isFreemail=true&r=3l29m&triedRedirect=true https://www.astralcodexten.com/p/why-does-ozempic-cure-all-d... Beyond their somewhat miraculous effects on obesity, they seem to have a wide variety of positive effects even for non-overweight people. They are likely the best and broadest thing we have for stopping negative addictions. They have incredibly positive effects for immune issues. Plus strong early trial results for Parkinson's, Alzheimers, and heart and kidney disease. I also think they are underrated and there may be some alpha in them for a few reasons: 1. People seem to hate the idea that someone can "cheat" at losing weight, almost seeming to hope they have some unknown side effect. 2. People seem to dismiss them as "only working because obesity causes all those issues", probably the biggest fallacy as we have evidence already, and I think will find much more, that the addictive, immune, kidney and heart effects are not due to weight loss/fasting. 3. People don't seem to realize how huge a deal it is if they do have a strong effect on immune issues - immune system issues underly so many health issues of different names from allergies to Alzheimers to all sorts of terrible diseases, and I now know a couple non-overweight people who have reported nearly miraculous results with them. 4. Their effects on addiction likewise just by themselves are big. Another friend/smoker since high school, smokes nearly a pack a day tried it and for the first time since HS didn't smoke a cigarette for a whole day - multiple days in a row. BTW it seems tirzepatide is significantly better for at least some of these effects than semaglutide.

user_7832 2y ago
What's slightly interesting to me is that some effects of adhd medications (particularly methylphenidate) sound quite similar - it too (can) change motivation regarding food (and actually can make unhealthy donuts seem disgusting) and of course suppresses apptetite (sometimes a little too much). I'd love to know if anyone who's taken both mph & a GLP-1 agonist how similar/different they are. (There's other interesting aspects of mph too - like how it can change sensitivities - and actually make light mode not feel like your eyes are on fire! - but that's a comment probably for another time.)
- nwienert 2y ago

9dev 2y ago

Not the answer you’re looking for, but mRNA vaccines as used for COVID are nothing short of a miracle. The bioengineering behind them, the logistics of it all—it was incredible.

kev009 2y ago
Maybe if it did what they said it would instead of moving the goal posts around to fit what actually happened.
chriscappuccio 2y ago
An incredible waste you mean?

thomasfedb 2y ago

Paracetamol (acetaminophen) - a fairly effective, synergistic, non-addictive, predictably dosed, analgesic.

akoboldfrying 2y ago
Which, TTBOMK, we still don't understand the mechanism of at all. But yes, it's fantastic stuff!
- car 2y ago
  ttbomk?
  - akoboldfrying 2y ago
    To the best of my knowledge
The_Colonel 2y ago
It's not addictive, but you gain tolerance. IIRC it's also hard on liver, esp. in combination with alcohol (which js unfortunate since it's otherwise good for hangover).
- car 2y ago
  Correct, makes for a nasty death. ~8 grams and your liver is toast. https://en.wikipedia.org/wiki/Paracetamol_poisoning https://en.wikipedia.org/wiki/Paracetamol_poisoning
- arcticbull 2y ago
  Leading cause of acute liver failure in the US, because the active dose is far closer to the lethal dose than many other OTC drugs. Not clear to me it would actually be approved if it were submitted today. It is particularly neat because it's not just a pain suppressant, it's a general emotion suppressant. > ... [it] blunts physical and social pain by reducing activation in brain areas (i.e. anterior insula and anterior cingulate) thought to be related to emotional awareness and motivation. [1] It also reduces the empathy for pain. [2] [1] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6455058/ https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6455058/ [2] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5015806/ https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5015806/

arcticbull 2y ago

Rapamycin, maybe metformin - both for life extension and to reduce the incidence of cancer and CVD.

oezi 2y ago

Your question should be split into two parts: - Miracle drugs for curing ailments. We have plenty of those. - Miracle drugs for enhancing beyond normal. Many things which work also have serious side-effects. Most things which are peddled with prescription don't have any effect.

pshirshov 2y ago

Thymopoetin analogues (or bovine one but there are more associated risks).A single injection makes you feel tens of years younger for a short time and wipes chronic infections.